香水中邻苯二甲酸酯总量测定及其暴露评估

发布时间：2019-02-22 14:13

【摘要】：建立了快速测定香水中邻苯二甲酸酯(PAEs)的前处理方法。将香水中的PAEs水解为邻苯二甲酸(PA),再利用磷酸三丁酯萃取酸化液中的PA,使用高效液相色谱-二极管阵列检测器定量分析,并评估了PAEs的暴露量。实验考察并优化了影响PAEs水解率的因素,包括KOH的浓度和体积、乙醇的体积、水解时间和温度,优化后的水解条件:10 mL 4 mol/L KOH,1 mL乙醇,水解时间20 min,水解温度80℃。目标分析物的线性范围为3~240μmol/L(R2=0.999 1),LOD和LOQ分别为4.6μmol/kg和5.9μmol/kg,加标回收率为83.4%~92.7%,日内和日间精密度(RSD)不大于6.8%(n=5)。选择35种香水进行测定,PAEs总量范围在LOD~77.738 mmol/kg之间,成年女性经由香水途径接触PAEs的最大暴露水平为0.474 2μg/(kg·d)。该方法前处理过程简单,可靠性高,适用范围广,可以作为检测香水中PAEs的新选择。
[Abstract]:A rapid method for the determination of phthalate (PAEs) in perfume was established. PAEs in perfume was hydrolyzed to (PA), phthalate and then extracted with tributyl phosphate to extract PA, from acidification solution. The content of PAEs was evaluated by high performance liquid chromatography-diode array detector. The factors affecting the hydrolysis rate of PAEs were investigated and optimized, including the concentration and volume of KOH, the volume of ethanol, the hydrolysis time and temperature, and the optimized hydrolysis conditions: 10 mL 4 mol/L KOH,1 mL ethanol and 20 min, hydrolysis time. The hydrolysis temperature is 80 鈩，

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