叔丁醇钾催化芳甲基叠氮化合物合成芳醛和芳酮的反应研究
发布时间：2019-06-21 12:38
【摘要】：对叔丁醇钾参与下芳甲基叠氮发生脱氮、水解反应进行了深入研究,得到芳甲醛.实验中,探讨了碱、水解条件、溶剂及碱量对苯甲醛反应产率的影响.研究发现,以N,N-二甲基甲酰胺(DMF)为溶剂,以叔丁醇钾(t-BuOK)为碱,反应效果最佳,以83%的产率得到苯甲醛.同时,对不同结构的叠氮化合物进行了考察,取代苯甲基叠氮能够顺利反应,得到相应的芳醛和芳酮,产率38%~87%,其他芳甲基叠氮化合物反应效果差.根据控制实验,探讨了反应机理.
[Abstract]:The denitrification and hydrolysis of arylmethyl azide with the participation of potassium tert-butylalcohol were studied to obtain aromatic formaldehyde. The effects of alkali, hydrolysis conditions, solvent and alkali content on the yield of benzaldehyde were discussed. It was found that benzaldehyde was obtained with N, N-dimethyl formamide (DMF) as solvent and potassium tert-butylalcohol (t-BuOK) as base. Benzaldehyde was obtained in 83% yield. At the same time, azide compounds with different structures were investigated. Substituted phenylmethyl azide could react smoothly, and the corresponding aromatic alaldehyde and aromatic ketone were obtained, the yield was 38% 鈮，
本文编号：2504082
[Abstract]:The denitrification and hydrolysis of arylmethyl azide with the participation of potassium tert-butylalcohol were studied to obtain aromatic formaldehyde. The effects of alkali, hydrolysis conditions, solvent and alkali content on the yield of benzaldehyde were discussed. It was found that benzaldehyde was obtained with N, N-dimethyl formamide (DMF) as solvent and potassium tert-butylalcohol (t-BuOK) as base. Benzaldehyde was obtained in 83% yield. At the same time, azide compounds with different structures were investigated. Substituted phenylmethyl azide could react smoothly, and the corresponding aromatic alaldehyde and aromatic ketone were obtained, the yield was 38% 鈮，
本文编号：2504082
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