无创血糖检测及其实验研究

发布时间：2018-06-28 01:30

本文选题：糖尿病 + 近红外　；参考：《江西科技师范大学》2014年硕士论文

【摘要】：随着我国人民生活水平的提高、劳动强度的减少以及生活方式的改变，糖尿病人也日趋增加。糖尿病（diabetes mellitus，DM）又称“沉默杀手”，是继肿瘤、心血管疾病之后的第三大慢性非传染性疾病，伴随多种高危并发症，严重威胁生命健康。很多患者因为缺乏对糖尿病的正确认识，，使糖尿病的控制受到了极大的影响。如果能够对病人加以争取的健康教育，这将对减轻或者避免糖尿病并发症的产生，提高病人的生活质量具有重要的意义。在近红外区域（780-2400nm），可以对人体进行非侵入性血糖检测。本文根据这一理论，结合光声测量原理、光声信号强度与溶液浓度关系理论，提出了基于光声效应的无创血糖检测这一研究。通过使用激光器、可调光路、检测平台、信号处理模块和数据显示等设备，组成了一套葡萄糖水溶液浓度的检测系统。确定激光作用在葡萄糖溶液中产生了声信号，并分析讨论了近红外区域的最优波长。多次重复进行实验，通过最小二乘法对实验数据进行拟合，提高了葡萄糖水溶液的测量精度。针对上述结果，优化实验平台、改进各个硬件单元、对实验所得声信号进行去噪，提高了信噪比，获得了更平滑的实验波形以及更好的实验数据。最后，对数据进行计算和拟合分析误差，进一步证实了光声测量血糖的可行性。但是实验系统还不够稳定，误差还比较大，还需要后续进一步的改进与提高。
[Abstract]:With the improvement of people's living standard, the decrease of labor intensity and the change of life style, the number of diabetics is increasing day by day. Diabetes mellitus (diabetes mellitus), also known as "silent killer", is the third largest chronic non-communicable disease after tumor and cardiovascular disease. With many high risk complications, it is a serious threat to life and health. The control of diabetes is greatly affected by the lack of correct understanding of diabetes in many patients. If we can strive for the health education of the patients, it will be of great significance to alleviate or avoid the complications of diabetes and improve the quality of life of the patients. In the near infrared region (780-2400nm), non-invasive blood glucose can be detected in the human body. According to this theory, combining with the principle of photoacoustic measurement and the theory of relationship between the intensity of photoacoustic signal and the concentration of solution, a study of noninvasive blood glucose detection based on photoacoustic effect is proposed in this paper. By using laser, tunable light path, detection platform, signal processing module and data display equipment, a set of glucose aqueous solution concentration detection system is constructed. The acoustic signal produced by laser in glucose solution was determined and the optimum wavelength of near infrared region was analyzed and discussed. Repeated experiments were carried out, and the experimental data were fitted by least square method, which improved the measuring accuracy of glucose aqueous solution. In view of the above results, the experimental platform is optimized, each hardware unit is improved, the acoustic signal is de-noised, the signal-to-noise ratio is improved, and a smoother experimental waveform and better experimental data are obtained. Finally, the calculation and fitting error of the data confirmed the feasibility of the photoacoustic measurement of blood glucose. However, the experimental system is not stable enough, the error is still relatively large, and need further improvement and improvement.
【学位授予单位】：江西科技师范大学
【学位级别】：硕士
【学位授予年份】：2014
【分类号】：R587.1;TN911.7

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