低频重复经颅磁刺激刺激初级运动皮层对大脑功能连接影响的研究

发布时间：2018-04-01 18:56

本文选题：低频重复经颅磁刺激　切入点：脑电　出处：《生物医学工程学杂志》2017年04期

【摘要】：重复经颅磁刺激(rTMS)能对刺激脑区及与其相连接的远端脑区产生影响。本文将从大脑功能连接、脑区之间相互协调工作状态改变的角度,研究低频rTMS刺激脑初级运动皮层对大脑的影响作用。募集了10名健康受试者,采用1 Hz rTMS刺激脑初级运动皮层20 min,采集刺激前后1 min闭目静息状态下的脑电(EEG)数据。对EEG进行相位同步分析,建立脑功能网络,并计算脑功能网络特征参数。最后使用符号秩和检验进行统计学分析。结果表明,低频rTMS刺激使大脑alpha频段全局相位同步指数显著降低(P0.05)。两两脑区分析表现为刺激侧的运动皮层与额叶皮层和顶叶皮层、非刺激侧顶叶皮层与双侧额叶皮层之间alpha频段相位同步显著降低。alpha频段脑功能网络的平均度、全局效率降低(P0.05),平均最短路径长度显著增加(P0.05)。表明低频rTMS使脑功能网络的信息传输变慢,传输效率变低。本文从大脑功能连接性的角度上证明了低频rTMS对大脑活动的抑制作用,说明低频rTMS能够对刺激脑区及与刺激脑区相连接的远端脑区产生影响。本研究有望为低频rTMS应用于临床疾病的治疗提供一定的指导。
[Abstract]:Repetitive transcranial magnetic stimulation (TMS) can affect the stimulation of the brain region and the distal brain region associated with it. To study the effects of low-frequency rTMS stimulation on the brain of the primary motor cortex. Ten healthy subjects were recruited. The cerebral primary motor cortex was stimulated with 1 Hz rTMS for 20 minutes, and the EEG EGG data were collected before and after 1 min closed eyes rest. The phase synchronization analysis of EEG was carried out to establish the brain functional network. The characteristic parameters of brain functional network are calculated. Finally, the symbolic rank sum test is used for statistical analysis. The results show that, Low frequency rTMS stimulation significantly reduced the global phase synchronization index (P0.05) of the brain alpha frequency. The results of two brain regions were as follows: motor cortex, frontal cortex and parietal cortex. The phase synchronization of alpha band between non-stimulative parietal cortex and bilateral frontal cortex significantly decreased the average of brain functional network in the. Alpha band. The global efficiency is reduced and the average shortest path length is significantly increased. The results show that the low frequency rTMS makes the information transmission of the brain functional network slow and the transmission efficiency lower. This paper proves the inhibitory effect of low frequency rTMS on brain activity from the point of view of brain functional connectivity. This study is expected to provide guidance for the application of low-frequency rTMS in the treatment of clinical diseases.
【作者单位】：中国医学科学院北京协和医学院生物医学工程研究所;中国医学科学院神经科学中心;
【基金】：国家自然科学基金仪器专项(81127003) 中国医学科学院医学与健康科技创新工程项目(2016-I2M-1004) 天津市科技支撑计划重点项目(17YFZCSY00730)
【分类号】：R741;TN911.7

【相似文献】