W-Pt微纳热电偶批量制备装置的设计与实现

发布时间：2018-01-17 02:10

本文关键词：W-Pt微纳热电偶批量制备装置的设计与实现　出处：《东南大学学报(自然科学版)》2015年04期 　论文类型：期刊论文

【摘要】：为了提高能应用于单细胞温度测量实验的W-Pt微纳热电偶的制作效率和稳定性,采用自动化控制技术完成W-Pt微纳热电偶批量制备系统的设计和实现.采用模块化设计方式,分别完成系统整体结构、电气控制系统部分的设计与实现,采用扫描电子显微镜、光学显微镜和水浴定标系统研究该系统制作的W-Pt微纳热电偶参数,包括W针尖端曲率半径、尖端锥角、裸露基极长度和Seeback系数.研究表明:该系统可实现快速制作性能稳定的W-Pt微纳热电偶,制作的大部分热电偶尖端曲率半径小于500 nm,锥角小于18°,裸露基极长度小于100μm,Seeback系数为4~8μV/K,可很好地应用于单细胞温度测量实验.
[Abstract]:In order to improve the fabrication efficiency and stability of W-Pt micro-nano thermocouple which can be used in single-cell temperature measurement experiment. The design and implementation of W-Pt micro-nano thermocouple batch preparation system are completed by using automatic control technology, and the whole structure of the system and the electrical control system part are designed and implemented respectively by modular design method. The parameters of W-Pt micro-nano thermocouple were studied by scanning electron microscope, optical microscope and water bath calibration system, including the curvature radius of the tip of the W needle and the tip cone angle. The length of bare substrate and the Seeback coefficient. The results show that the system can be used to fabricate stable W-Pt micro-nano thermocouple. The curvature radius of the tip of the thermocouple is less than 500 nm, the cone angle is less than 18 掳, and the length of the bare base is less than 100 渭 m. The Seeback coefficient is 4 ~ 8 渭 V / K. It can be well used in single cell temperature measurement experiment.
【作者单位】：东南大学生物电子学国家重点实验室;江苏省生物材料和器件重点实验室;
【基金】：国家重大科学研究计划资助项目(2011CB933503)
【分类号】：TH811
【正文快照】： 温度对生命体的影响体现在对构成生命体的基本单位——细胞的影响[1].现代研究表明,温度通过调控细胞内部生化反应进而影响细胞的功能[2].对单个细胞温度的检测分析将有助于更加全面地了解细胞内部调控机制,例如单细胞温度测量能为肿瘤热疗、检测癌细胞新陈代谢活动、甲状腺肿

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