用于GERD诊断的胶囊式pH监测系统的初步研发

发布时间：2018-02-26 08:28

本文关键词： GERD pH值 CC2540 无线传输应用程序　出处：《南京航空航天大学》2016年硕士论文　论文类型：学位论文

【摘要】：近年来,居民饮食结构的变化导致胃食管反流病(Gastro Esophageal Reflux Disease,GERD)的发病率逐年上升。临床医学中,医生通过鼻腔插入患者的食管下括约肌(Lower Esophageal Sphincter,LES)上5cm处一支pH监测电极,与体外数据记录仪相连以监测患者食道pH值,从而确诊GERD。这种pH监测方法不仅会影响患者的生活、给患者的食管壁带来不适,而且由于电极的移动也会导致测量结果不够准确。本课题结合GERD诊断的现状,基于可吞服电子胶囊(Swallow Electronic Capsule,SEC)这一概念,初步设计了一种用于GERD诊断的胶囊式pH监测系统。论文的主要内容包括:(1)综合对比各种pH电极的性能,选择复合玻璃电极作为测量电极并对其进行了实验验证,实验表明其稳定度好、准确度高。(2)基于数据采集、处理、无线传输的功能要求,选择了TI公司的CC2540微控制芯片,以此芯片为核心设计并实现了上述功能一体化的采集系统。该系统可以进行准确的pH值监测、实时的数据处理和同步的无线数据传输。(3)基于便携远程医疗的理念,设计了基于Android系统的手机应用程序,实现了来自CC2450的数据的无线接收、显示和保存,并通过相关测试证明了所设计的应用程序可以实现数据传输的准确性。(4)设计了相关测试验方案验证了所搭建系统pH值测量的稳定性和准确性。最后,设计并完成了动物(新西兰兔)的在体实验,表明所研发的用于GERD诊断的胶囊式pH监测系统的初步可行性。本课题在GERD的诊断治疗方面具有独特应用价值,通过以后的逐步完善有望应用于临床。此外,该项技术也可以为非医学领域的pH监测提供一种新的技术途径。
[Abstract]:In recent years, the change of people's diet structure lead to gastroesophageal reflux disease (Gastro Esophageal Reflux Disease, GERD) incidence increased year by year. The clinical medicine, the doctor inserted through the nasal cavity in patients with lower esophageal sphincter (Lower Esophageal Sphincter, LES 5cm) on a pH monitor electrode is connected with the data logger to monitor patients with esophageal pH value, thus confirmed GERD. this pH monitoring method will not only affect the life of the patients, to patients with esophageal wall discomfort, and because the movement of the electrode will lead to the result is not accurate enough. This study combined the current status of GERD diagnosis, swallow capsules (Swallow Electronic Capsule, based on the concept of SEC) and the preliminary design for a capsule type pH monitoring system for the diagnosis of GERD. The main contents of this paper include: (1) the performance of comprehensive comparison of various pH electrode, composite glass electrode as measured The amount of electrode and verified the result of the experiment shows that the good stability and high accuracy. (2) based on data acquisition, wireless transmission, functional requirements, the company chose TI CC2540 micro control chip, the chip is used as the core design and implementation of the acquisition system. The system function integration for accurate pH monitoring, real-time data processing and wireless data transmission synchronization. (3) portable telemedicine based on the concept of the design of the Android system based on mobile phone application, realize the wireless receiving data from the CC2450, display and preservation, and proved the accuracy of the designed application can be achieved the data transmission through the relevant test. (4) design related test scheme is verified by building the system pH value measurement stability and accuracy. Finally, the design and completion of the animal (rabbit) in vivo experiment table For preliminary feasibility of capsule type pH monitoring system GERD in the diagnosis of the Ming development. This topic has a unique application value in the diagnosis and treatment of GERD, the future is expected to improve gradually in clinical application. In addition, provides a new approach for monitoring the pH technology also can be a non medical field.

【学位授予单位】：南京航空航天大学
【学位级别】：硕士
【学位授予年份】：2016
【分类号】：R197.39

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