一种基于fMRI的味觉刺激装置的设计与验证

发布时间：2018-08-14 12:25

【摘要】：功能磁共振成像(f MRI)技术是一种新型的用于研究人脑功能活动的方法,通常作为一种揭示脑和思维关系的一种重要手段,在分析高级神经生理和神经心理活动方面具有重要的作用。目前,在已知感官中,视觉、听觉刺激装置发展比较成熟,国内外已有多家公司供应商用化产品,味觉刺激尚在理论阶段,通过味觉刺激进行相关脑科学研究相对较少。可能存在的原因主要有:1)味觉刺激装置通常需要根据各实验室实际要求进行搭建,没有一定的标准及成型的技术方案;2)缺乏专用的、自动化的且能够同时满足各种f MRI实验要求的味觉刺激装置;3)另外,味觉刺激装置中液体量的设定及对废液的处理方式因实验而异,液体量过大或长时间投送,需要单独设计废液处理装置;4)味觉f MRI实验的设计模式需要根据具体实验进行进一步研究。根据目前味觉刺激装置发展面临的问题,本文主要进行了一种f MRI的味觉刺激装置的设计与验证,并通过味觉f MRI实验对该设计的可用性进行了验证。具体成果如下:1)对目前已有的味觉刺激装置进行了分析和总结,从多路刺激、单一刺激、自动控制、成像同步、电磁兼容等方面进行需求分析,得出了味觉刺激装置的设计方案;2)方案中,使用Lab VIEW软件编写上位机的软件平台,投送用户自定义的刺激序列;下位机利用以微控制器为核心的数字路,完成液体的精确投送;另外,设计了味觉刺激装置的液体输送通路;同时通过数据采集卡将上位机的刺激序列发送至下位机执行,完成实时定量的味觉刺激输送;3)设计并使用搭建的味觉刺激装置对6个被试进行了f MRI味觉实验,得到了甜、咸味觉刺激下的脑激活图和部分ROI(Region of Interest)的时间曲线,验证了该味觉刺激装置的可用性。
[Abstract]:Functional magnetic resonance imaging (f MRI) is a new method for studying the functional activities of human brain, which is usually used as an important means to reveal the relationship between the brain and the mind. It plays an important role in the analysis of advanced neurophysiology and neuropsychological activities. At present, among the known senses, the visual and auditory stimuli are relatively mature. There are many companies at home and abroad using chemical products, taste stimuli are still in the theoretical stage, and there is relatively little research on related brain science through taste stimuli. The main reasons for this are: 1) the taste stimulator usually needs to be built according to the actual requirements of each laboratory, and there is no certain standard and no special technical scheme for shaping it. An automatic taste stimulator that can meet the requirements of various f MRI experiments at the same time) in addition, the setting of liquid volume and the treatment of waste liquid in the taste stimulator vary from experiment to experiment, and the volume of liquid is too large or long time. The design pattern of taste f MRI experiment needs to be further studied according to the specific experiment. According to the problems in the development of taste stimulator, this paper mainly designs and verifies a kind of f MRI taste stimulator, and verifies the usability of the design through taste f MRI experiment. The concrete results are as follows: 1) We have analyzed and summarized the existing taste stimuli, and analyzed the needs from the aspects of multi-channel stimulation, single stimulus, automatic control, imaging synchronization, electromagnetic compatibility, etc. In the design scheme of taste stimulator, Lab VIEW software is used to write the software platform of upper computer to send the user-defined stimulation sequence, and the lower computer makes use of the digital path with microcontroller as the core to complete the accurate delivery of liquid. In addition, the liquid transmission path of the taste stimulator is designed. At the same time, the stimulation sequence of the upper computer is sent to the lower computer through the data acquisition card. The f MRI taste test of 6 subjects was carried out with the designed and constructed taste stimulator. The brain activation map and partial ROI (Region of Interest) time curve of sweet and salty taste stimuli were obtained. The availability of the taste stimulator is verified.
【学位授予单位】：中国科学院研究生院(长春光学精密机械与物理研究所)
【学位级别】：硕士
【学位授予年份】：2015
【分类号】：TH789

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