基于大鼠皮层微电刺激反馈的闭环控制系统实现

发布时间：2018-01-16 14:10

本文关键词：基于大鼠皮层微电刺激反馈的闭环控制系统实现　出处：《浙江大学》2017年硕士论文　论文类型：学位论文

【摘要】：脑机接口技术旨在实现大脑和外界环境之间地直接信息交互,为残疾患者重建运动或感觉功能提供一种潜在的解决方案。目前主要的脑机接口技术是利用大脑的神经信号控制外部机械设备,外界信息多用视觉或听觉等自然感觉进行反馈。这类反馈方式的缺点在于:(1)患者听觉或视觉输入有损伤时(失聪或失明)无法提供必要的信息反馈;(2)某些触觉信息(如温度、物体表面粗糙度等)无法用视觉反馈进行替代。因此尝试在神经信号控制外部设备时,将外界信息以皮层微电刺激形式反馈回大脑,构成闭环控制系统,有利于实验动物对外部设备进行更精确地控制,实现大脑与外界之间直接进行信息双向交互。本文以大鼠为研究对象,以皮层微电刺激作为信息反馈方式构建闭环控制系统为研究目标,提出了大鼠利用神经元发放状态控制机械手,并以不同电流强度电刺激反馈外界温度的实验方案。实验探究了大鼠对不同参数电刺激输入的区分能力,实现了大鼠利用脑电控制机械手运动,同时完成了皮层微电刺激在脑机接口中的应用研究,验证了将电刺激作为信息反馈方式的可行性以及电刺激信息反馈的有效性。具体内容包括:1)搭建了基于大鼠皮层微电刺激反馈的闭环控制研究平台。平台可实时采集大鼠行为学信号和神经元发放信息,进行在线分析处理,控制外部设备运动状态,同时对实验结果进行实时可视化显示。2)分别进行了基于大鼠的脑→机控制实验以及机→脑的皮层微电刺激区分实验,为后期进行皮层微电刺激在脑机接口的应用研究奠定基础。首先进行了电刺激区分训练,从行为学和电生理两个角度探究了大鼠对不同电流强度电刺激的区分能力,验证了电刺激作为信息输入方式的可行性。其次进行了大鼠利用神经元发放状态控制机械手的实验任务,分析了大鼠对运动皮层神经元发放率的调节能力。3)进行了皮层微电刺激反馈在脑机接口中的应用研究。在大鼠利用脑电控制机械手的同时将外界不同温度以皮层微电刺激形式反馈给大鼠。通过对大鼠行为学结果地分析,探究闭环控制系统的可行性以及电刺激在其中的信息反馈作用。本文的特点在于将不同电流强度的皮层微电刺激与外界温度建立对应关系,实现了基于大鼠的闭环控制系统,帮助实验对象与外界环境进行更好地信息交互,同时也为残障患者的运动和感觉功能重建提出了一种新的思路,具有重要的临床研究意义。
[Abstract]:Brain computer interface technology to achieve between brain and external environment to direct information, provide a potential solution for the reconstruction of disability in patients with motor or sensory function. The interface technology of brain computer is the main use of neural signals to control external devices of the brain, outside information by vision or hearing natural sensory feedback. Feedback the disadvantage of this type is: (1) patients with auditory or visual input damage (deaf or blind) can not provide the necessary information feedback; (2) some tactile information (such as temperature, surface roughness etc.) cannot use visual feedback instead. So try in neural signals to control external devices, will the external information in the cortex electrical stimulation form feedback to the brain, a closed-loop control system for experimental animal, more precise control of external equipment, between the brain and the outside world directly Information interactive. In this paper, the rats as the research object, the cortical electrical stimulation as a way to build information feedback loop control system as the research object, put forward using rat neuron state control manipulator, and different current intensity stimulation experiment outside temperature feedback. Experimental exploration of the rats to distinguish the ability of different electric stimulation parameters input, the EEG of rats using motion control of manipulator, and completed the application in brain-computer interface micro electric cortical stimulation, electrical stimulation will be verified as the feedback method of the feasibility and effectiveness of the stimulation of information feedback. The specific contents include: 1) build the closed loop of rat cortical electrical stimulation feedback control research platform based on real time acquisition behavior of rats and neuron signal information, on-line analysis processing, control department Preparation of the state of motion, and the experimental results in real time visualization of.2) were carried out based on the brain, experimental machine, machine control and cortical brain stimulation between experimental rats, micro electrical stimulation is applied in the study of brain computer interfaces and lay the foundation for the later cortex. Electrical stimulation training was first distinguished from. Two aspects of behavioral and electrophysiological studies on rats ability to distinguish different current intensity of electrical stimulation, electrical stimulation is verified the feasibility of the information input method. Secondly, the rats with neuronal firing experiment task state control of the manipulator, analyzes the rat firing rate adjustment ability of.3 on motor cortex neurons) the cortex electrical stimulation feedback application in brain computer interface. In rats by simultaneous EEG to control the manipulator to the outside world at different temperatures in the cortex electrical stimulation to form feedback Rat. The rat behavioral results analysis, explore the feasibility and the closed-loop control system of electrical stimulation feedback in the information. This article is characterized by the current strength of the different cortical electrical stimulation and the outside temperature to establish the correspondence between the closed loop control system based on experimental rats, help object with the outside world the environment for better information interaction, but also put forward a new idea for the motor and sensory function reconstruction of disabled patients, has important clinical significance.

【学位授予单位】：浙江大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：TP273;R49

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