微悬臂生物传感器

发布时间：2019-07-29 08:12

【摘要】：微悬臂生物传感器是基于原子力显微镜和生物传感器发展而来,具有无需标记、快速、实时、灵敏度高等优点,已广泛运用于生物医学、环境监测、医药、食品及军事等多个领域。微悬臂生物传感器已成为当前研究热点。本文对近年来微悬臂生物传感器的研究工作进行了综述,总结了微悬臂传感器中微悬臂梁的结构、工作模式、激励方法和检测方法。国内有关微悬臂传感器的综述多是着重于介绍微悬臂传感器的应用进展,而缺少对微悬臂传感器的检测方法或读出方式做全面而系统的介绍,本文不仅全面且系统地对微悬臂传感器的8种检测方法进行了详细的介绍和分析,还介绍了微悬臂梁的多种典型尺寸、外观和微悬臂传感器工作模式中的"热模式"。针对微悬臂传感器实现特定检测及提高灵敏度的目的,本文总结了微悬臂传感器的表面修饰方法,不仅介绍了国内外微悬臂生物传感器最新的应用动态,还介绍了一种具有自驱动自传感功能的新型微悬臂传感器,并对微悬臂生物传感器的应用前景作了探讨。
[Abstract]:Micro-cantilever biosensor is based on atomic force microscope and biosensor. It has many advantages, such as no marking, fast, real-time, high sensitivity and so on. It has been widely used in biomedicine, environmental monitoring, medicine, food and military and other fields. Micro-cantilever biosensor has become a hot research topic at present. In this paper, the research work of micro-cantilever biosensor in recent years is reviewed, and the structure, working mode, excitation method and detection method of micro-cantilever beam in micro-cantilever sensor are summarized. Most of the domestic reviews of micro-cantilever sensors focus on the application progress of micro-cantilever sensors, but lack of a comprehensive and systematic introduction to the detection methods or readout modes of micro-cantilever sensors. In this paper, not only eight detection methods of micro-cantilever sensors are introduced and analyzed in detail, but also a variety of typical dimensions of micro-cantilever sensors are introduced. Appearance and "thermal mode" in the working mode of the micro-cantilever sensor. Aiming at the purpose of realizing specific detection and improving sensitivity of micro-cantilever sensor, this paper summarizes the surface modification method of micro-cantilever sensor, not only introduces the latest application trends of micro-cantilever biosensor at home and abroad, but also introduces a new type of micro-cantilever sensor with self-driving self-sensing function, and discusses the application prospect of micro-cantilever biosensor.
【作者单位】：扬州大学化学化工学院;悉尼科技大学数学与物理科学学院;
【基金】：国家自然科学基金项目(No.21375116) 国家高技术研究发展计划(863)项目(No.2009AA03Z331) 江苏省大型科学仪器设备共享服务平台分析测试技术及方法研究课题(BZ201409)资助~~
【分类号】：TP212.3

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