脓毒症患者凝血功能异常的发生率以及其临床意义研究

发布时间：2017-12-31 01:24

本文关键词：脓毒症患者凝血功能异常的发生率以及其临床意义研究　出处：《河南医学研究》2017年04期 　论文类型：期刊论文

【摘要】：目的探讨脓毒症患者凝血功能异常的发生率以及其临床意义。方法回顾性分析2014年1月至2015年12月在安阳地区医院就诊的76例脓毒血症患者临床病例资料,比较患者住院后第1、7、14天时APTT、INR、PLT、D-dimer等指标变化情况。结果 76例患者住院第1、7、14天时出现凝血功能异常分别为29例、31例和34例,发生率为38.2%、40.8%和44.7%;治疗14 d后凝血异常组患者其APTT、INR、PLT水平与无凝血异常组患者比较,差异均无统计学意义(P0.05);凝血异常组D-dimer水平显著高于凝血正常组,差异具有统计学意义(P0.05)。患者SOFA、APACHEⅡ评分随着其D-dimer水平的增加而增加,差异具有统计学意义(P0.05)。结论脓毒血症患者中约有半数具有一定程度的凝血功能异常,D-dimer指标与脓毒血症程度有关,因此在患者早期可对D-dimer进行检测以便确诊。
[Abstract]:Objective to investigate the incidence of coagulation dysfunction in sepsis patients and its clinical significance. Methods a retrospective analysis from January 2014 to December 2015 in the Anyang area hospital for treatment of 76 cases of sepsis in patients with clinical data, comparison of patients after 1,7,14 days when APTT, INR, PLT, D-dimer and other indicators of changes. The results of 76 cases of hospitalized patients the first 1,7,14 days when coagulation abnormalities were 29 cases, 31 cases and 34 cases, the incidence rate was 38.2%, 40.8% and 44.7%; 14 d after treatment of abnormal coagulation of patients whose APTT, INR, PLT level and no abnormal coagulation group of patients, there were no significant differences in the level of D-dimer (P0.05); abnormal coagulation blood group was significantly higher than the normal group, the difference was statistically significant (P0.05). SOFA patients, APACHE score increased with the increase of D-dimer level, the difference was statistically significant (P0.05). Conclusion sepsis in patients with ca. Half of them have a certain degree of abnormal coagulation function, and the D-dimer index is associated with the degree of sepsis, so D-dimer can be detected early in the patient so as to confirm the diagnosis.

【作者单位】：安阳地区医院血液科;
【分类号】：R459.7
【正文快照】： 临床对重度脓毒血症的临床治疗未获得突破性发展,可能与患者自身状态有关[1]。近几年来,对脓毒血症的研究逐渐倾向于宿主因素对致病微生物的抵抗,特别是凝血系统的激活。文献报道,感染引起的凝血系统被异常激活后可能造成组织和器官功能发生异常[2]。为研究脓毒症患者凝血功能

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