原发性肾病综合征患者尿路感染特征与病原菌耐药性分析

发布时间：2017-12-31 07:47

本文关键词：原发性肾病综合征患者尿路感染特征与病原菌耐药性分析　出处：《中华医院感染学杂志》2017年22期 　论文类型：期刊论文

【摘要】：目的探讨原发性肾病综合征(PNS)患者尿路感染的临床特征、病原菌分布及耐药性。方法选取医院2014年4月-2017年4月收治的375例PNS,根据是否发生尿路感染分为感染组和非感染组,分析感染患者病原菌分布及耐药性,以及发生感染的临床特征。结果 375例PNS患者共发生67例尿路感染,感染率17.87%;共分离83株病原菌,其中革兰阴性菌67株,占80.72%,革兰阳性菌11株,占13.25%,真菌5株,占6.03%;大肠埃希菌对氨苄西林耐药率最高为82.86%,对亚胺培南耐药率最低为5.71%;肺炎克雷伯菌对氨苄西林耐药率最高为75.00%,对亚胺培南耐药率最低;表皮葡萄球菌对庆大霉素的耐药率最高为100.00%,对左氧氟沙星和头孢哌酮耐药性最低为0;感染组患者的24h尿蛋白定量、尿素氮、血肌酐明显高于非感染组,住院时间长于非感染组,而血清白蛋白及IgG水平明显低于非感染组。结论应根据感染的临床特征及病原菌耐药性,合理选择抗菌药物。
[Abstract]:Objective to investigate the primary nephrotic syndrome (PNS) clinical characteristics of urinary tract infection patients, pathogen distribution and drug resistance. Methods 375 cases of PNS hospital in April 2014 -2017 year in April, according to the occurrence of urinary tract infection were divided into infection group and non infection group, infection pathogen distribution and drug resistance of patients with disease, and the clinical features of infection. Results a total of 375 PNS patients and 67 cases of urinary tract infection, the infection rate was 17.87%; 83 strains of pathogenic bacteria were isolated, including 67 strains of gram negative bacteria, accounted for 80.72%, 11 strains of gram positive bacteria accounted for 13.25%, 5 strains of fungi, accounting for 6.03% of Escherichia coli to ampicillin resistance; the highest rate was 82.86%, the resistant rate of imipenem was the lowest of 5.71%; Klebsiella pneumoniae resistant rate to ampicillin was 75%, the lowest rate of imipenem resistant Staphylococcus epidermidis; resistant to gentamicin for the highest rate of 100%, and to levofloxacin A minimum of 0 of cefoperazone resistance infection; 24h urine protein, urea nitrogen group, serum creatinine was significantly higher than that in the non infection group, the hospitalization time is longer than the non infected group, while serum albumin and IgG levels were significantly lower than those in the non infected group. Conclusions according to the clinical characteristics and drug resistance of pathogen infection, reasonable selection of antibiotics.

【作者单位】：青海省人民医院肾内科;
【基金】：青海省科学技术厅科技计划基金资助项目(2014-ZJ-747)
【分类号】：R446.5;R692
【正文快照】： 30%[1-2]。由于受到疾病本身的特征、患者机体状况等方面的影响,PNS患者常常并发尿路感染,合并尿路感染会加重PNS患者的肾脏损害,使病情恶化或者反复,甚至进展为肾功能衰竭。因此,有效的预防和控制感染率对改善PNS患者预后具有重要的临床价值[3]。本研究选取医院2014年4月-201

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