基于心血管事件的促甲状腺激素参考范围上限值研究

发布时间：2018-01-02 21:34

本文关键词：基于心血管事件的促甲状腺激素参考范围上限值研究　出处：《中国全科医学》2017年31期 　论文类型：期刊论文

【摘要】：目的从心血管事件角度,探讨促甲状腺激素(TSH)参考范围上限值。方法本研究为"中国2型糖尿病患者恶性肿瘤发生风险的流行病学研究(REACTION研究)"的附带研究,研究时间为2011年5—8月,研究对象为贵阳市云岩区血清TSH水平在参考范围内的40岁及以上居民7 711例。根据参考范围内的TSH水平,将纳入受试者分为4组:第1组,TSH 0.550~1.499 m U/L,1 297例;第2组,TSH 1.500~2.499 m U/L,2 623例;第3组,TSH2.500~3.499 m U/L,2 188例;第4组,TSH 3.500~4.780 m U/L,1 603例。比较4组受试者的心血管事件患病率,并采用Logistic回归分析探讨参考范围内TSH水平对患心血管事件的影响。结果 4组受试者TSH水平分别为(1.148±0.251)、(2.004±0.284)、(2.977±0.286)、(4.078±0.363)m U/L。4组受试者性别、总胆固醇(TC)、三酰甘油(TG)、低密度脂蛋白胆固醇(LDL-C)比较,差异有统计学意义(P0.05);平均年龄、BMI、腰围、收缩压、舒张压、空腹血糖(FPG)、高密度脂蛋白胆固醇(HDL-C)比较,差异无统计学意义(P0.05)。4组受试者的心血管事件患病率比较,差异无统计学意义(P0.05)。Logistic回归分析结果显示,参考范围内TSH水平不是患心血管事件的影响因素(P0.05);分别对性别、年龄和性别、年龄、FPG、TC、TG、LDL-C、HDL-C进行调整后,参考范围内TSH水平仍不是患心血管事件的影响因素(P0.05)。结论参考范围内不同TSH水平者的心血管事件患病率相似,未发现降低TSH参考范围上限值对降低心血管事件患病率有益的证据。
[Abstract]:Objective to study cardiovascular events. To explore the upper limit of TSHs reference range. Methods this study is an epidemiological study on the risk of malignant tumor in type 2 diabetic patients in China. "incidental to the study. The study time was from May to August, 2011. The subjects of the study were 7 711 residents aged 40 years and above whose serum TSH level was within the reference range in Yunyan District of Guiyang City. According to the TSH level within the reference range. The subjects were divided into four groups: group 1: 1 297 cases of TSH 0.550 ~ 1.499 m / L ~ (-1); Group 2: TSH 1.500 ~ 2.499 UL / L 2 623 cases; Group 3: TSH2.500 ~ 3.499 MU / L ~ (2 188); The prevalence of cardiovascular events in group 4 was compared with that in group 4 (TSH 3.500 ~ 4.780 m / L = 1 603). Logistic regression analysis was used to investigate the effect of TSH level on cardiovascular events in the reference range. Results the TSH levels in the four groups were 1.148 卤0.251). 2. 004 卤0. 284 + 2. 977 卤0. 286mU / L.4 subjects' sex and total cholesterol (TC-) were 4. 078 卤0. 363mU / L.4 group (P < 0. 05). The difference of low density lipoprotein cholesterol (LDL-C) and triacylglycerol (TGG) was statistically significant (P 0.05). The mean age of BMI, waist circumference, systolic blood pressure, diastolic blood pressure, fasting blood glucose and high density lipoprotein cholesterol (HDL-C) were compared. There was no significant difference in the prevalence of cardiovascular events in the subjects of P0.054.The results of logistic regression analysis showed that there was no significant difference between the two groups. The level of TSH in the reference range was not the influencing factor of cardiovascular events (P 0.05). The HDL-C levels of LDL-C in TGN were adjusted after the adjustment of sex, age and age. The level of TSH within the reference range is still not an influential factor for cardiovascular events. Conclusion the prevalence of cardiovascular events in patients with different TSH levels within the reference range is similar. No evidence was found that lowering the upper limit of TSH reference range was beneficial to lower cardiovascular event prevalence.
【作者单位】：贵州医科大学附属医院内分泌代谢病科;
【基金】：基金项目:贵州省省长资金临床应用课题专项研究(黔省专合字2012-100号)
【分类号】：R446.6
【正文快照】： TSH Upper Reference Limit and Cardiovascular Events YUAN Li-li,PENG Nian-chun*,SHI Li-xin,ZHANG Qiao,HU Ying,ZHANG Miao,ZHUANG Hui-junDepartment of Endocrinology,The Affiliated Hospital of Guizhou Medical University,Guiyang 550004,China*Corresponding aut

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