2013-2014年围产期孕妇携带B族链球菌的血清型与耐药分析

发布时间：2018-01-03 04:20

  本文关键词：2013-2014年围产期孕妇携带B族链球菌的血清型与耐药分析　出处：《中国感染与化疗杂志》2017年05期 　论文类型：期刊论文

  更多相关文章： 围产期 B族链球菌 血清型 药敏试验

【摘要】：目的对围产期孕妇B族链球菌(GBS)携带株的血清型及药敏结果进行分析。方法收集妊娠35~37周孕妇的阴道和直肠分泌物标本,进行细菌培养和鉴定,并统计其阳性率。采用凝集法进行血清学分型,用纸片扩散法进行药敏试验,参照2009版CLSI标准判定药敏结果,采用WHONET 5.6软件进行统计分析。结果 2 533例围产期孕妇进行GBS的检测,检出GBS 264株,阳性率10.4%(264/2 533)。并对153株菌进行了血清分型,其中Ⅲ型占54.9%(84/153)、Ⅰa型占17.6%(27/153)、Ⅰb型占13.1%(20/153);药敏试验显示:该菌对青霉素、头孢曲松、万古霉素均敏感,对左氧氟沙星、红霉素和克林霉素的耐药率分别是32.9%、68.1%和62.1%;对不同血清型的耐药情况分析发现,Ⅲ型菌株对以上3种药物的耐药率明显高于其他血清型菌株。结论孕妇阴道和直肠均为GBS的定植部位,建议应对孕妇的阴道和直肠分泌物同时送检以提高其检出率;Ⅲ型是GBS主要的血清型;青霉素仍可作为孕产妇及新生儿治疗GBS感染的首选药物,GBS阳性的孕产妇应立即进行干预治疗,以保证围产儿健康。
[Abstract]:Objective to analyze the serotype and drug sensitivity of group B streptococcus B carrying strain in perinatal period. Methods the vaginal and rectal secretions of pregnant women at 3537 weeks of gestation were collected. The bacteria were cultured and identified, and the positive rate was counted. The serological typing was carried out by agglutination method, the drug sensitivity test was carried out by disk diffusion method, and the drug sensitivity results were determined by referring to the 2009 CLSI standard. Results 2 533 cases of perinatal pregnant women were tested for GBS and 264 strains of GBS were detected. The positive rate was 10.4 / 264 / 25330.The serotyping of 153 strains of bacteria was carried out, of which type 鈪，

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