帕金森型多系统萎缩与帕金森病患者胼胝体损害的白质图定量研究
发布时间:2018-01-03 11:15
本文关键词:帕金森型多系统萎缩与帕金森病患者胼胝体损害的白质图定量研究 出处:《放射学实践》2017年06期 论文类型:期刊论文
【摘要】:目的:应用基于DTI的白质图分析(DTI-ABA)方法,探讨MSA-p及PD患者胼胝体解剖连接隐匿损伤及DTI在MSA-p及PD辅助鉴别诊断中的价值。方法:选择PD患者18例,MSA-P患者18例,性别、年龄相匹配的健康对照(HC)20例行DTI扫描,应用DTI-ABA方法获得胼胝体各部分的DTI参数值,其参数包括FA、MD、RD、AD,进行3组数据比较分析,并行DTI参数与UPDRS-Ⅲ相关性分析。结果:与HC及MSA-p组比较,PD组胼胝体体部、压部、左毯部FA值降低(P0.05);膝部、体部、压部的MD值、AD值和RD值升高(P0.05)。MSA-p与HC相比胼胝体各部各DTI参数均无改变。PD组胼胝体膝部、体部及压部的FA值与UPDRS-Ⅲ得分负相关,体部、压部及双侧毯部的RD值与UPDRS-Ⅲ得分呈正相关。胼胝体体部的MD值、RD值诊断PD的敏感度、特异度分别为83.3%、94.7%以及77.8%、88.6%。结论:PD患者胼胝体存在隐匿性损伤,而在MSA-p患者未发现这种现象,DTI可在一定程度上可帮助MSA-p及PD的鉴别诊断。
[Abstract]:Objective: to apply DTI-ABA method based on DTI. Objective: to evaluate the value of MSA-p and PD in the differential diagnosis of MSA-p and PD. Methods: eighteen cases of PD were selected. In 18 patients with MSA-P, 20 healthy controls (sex and age matched) underwent DTI scanning. The DTI parameters of all parts of corpus callosum were obtained by DTI-ABA method. Three groups of data were compared and analyzed, and the correlation between DTI parameters and UPDRS- 鈪,
本文编号:1373642
本文链接:https://www.wllwen.com/linchuangyixuelunwen/1373642.html
最近更新
教材专著