红细胞分布宽度联合PCT对胰腺炎合并重症感染患者病情的评估

发布时间：2018-01-04 01:30

本文关键词：红细胞分布宽度联合PCT对胰腺炎合并重症感染患者病情的评估　出处：《中华医院感染学杂志》2017年14期 　论文类型：期刊论文

【摘要】：目的探讨联合检测红细胞分布宽度(RWD)和降钙素原(PCT)对于急性胰腺炎(AP)合并重症感染患者病情评估的效果,为临床治疗提供参考依据。方法选取2012年6月-2016年1月于医院就诊的急性胰腺炎患者122例,按疾病程度分为轻症急性胰腺炎(MAP)组68例和急性胰腺炎合并严重感染者(SAP)组54例,比较两组患者入院24h后临床指标。结果 SAP组PCT、RDW、超敏C-反应蛋白(hs-CRP)、肿瘤坏死因子-α(TNF-α)、白介素-8(IL-8)和急性生理及慢性健康(APACHEⅡ)评分均显著高于MAP组,差异均有统计学意义(P0.05);SAP组54例患者中,最终11例死亡,病死率为20.4%;死亡患者PCT、RDW、hs-CRP、TNF-α、IL-8和APACHEⅡ评分均显著高于存活患者,差异均有统计学意义(P0.05);SPearman相关性分析结果显示,PCT、RDW、hs-CRP、TNF-α和IL-8与APACHEⅡ评分均存在显著正相关性。结论联合检测红细胞体积分布宽度和降钙素原对于胰腺炎合并重症感染患者病情评估和预后判断具有重要意义,具有快速、简单、费用低廉的特点,可以考虑作为临床治疗胰腺炎合并重症感染患者的实时监测指标。
[Abstract]:Objective to explore the joint detection of red cell distribution width (RWD) and procalcitonin (PCT) for acute pancreatitis (AP) complicated with severe infection patient assessment results, provide a reference for clinical treatment. Methods 122 cases of June 2012 -2016 year in January the hospital in acute pancreatitis patients according to the extent of the disease is divided into light acute pancreatitis (MAP) group of 68 cases with acute pancreatitis and severe infection (SAP) group of 54 cases, the clinical indexes of the two groups were compared in patients hospitalized after 24h. Results in group SAP, PCT, RDW, high sensitive C- reactive protein (hs-CRP), tumor necrosis factor alpha (TNF- alpha, interleukin (-8) IL-8) and acute physiology and chronic health evaluation (APACHE II) were significantly higher than MAP group, the differences were statistically significant (P0.05); 54 cases in group SAP, 11 cases died, the mortality rate was 20.4%; the death of patients with PCT, RDW, hs-CRP, TNF- alpha, IL-8 and APACHE score were significantly higher than those in survival patients, The differences were statistically significant (P0.05); SPearman correlation analysis showed that PCT, RDW, hs-CRP, TNF- alpha and IL-8 and APACHE score were significantly positively correlated. Conclusion the combined detection of red blood cell volume distribution width and procalcitonin in acute pancreatitis complicated with severe infection in patients with disease assessment and prognosis has important significance, has fast, simple, low cost, can be considered as indicators of real-time monitoring for the clinical treatment of patients with acute pancreatitis complicated with severe infection.

【作者单位】：沧州市人民医院重症医学科;沧州市人民医院急诊科;沧州市人民医院妇产科;
【基金】：沧州市科技计划基金资助项目(141302061)
【分类号】：R446.1;R576
【正文快照】： 急性胰腺炎(AP)是常见的急腹症之一,其临床特征为胰腺局部炎症反应,伴或不伴其他器官功能改变,具有病情多变,发展迅速的特点[1]。临床上,急性胰腺炎可分为轻症急性胰腺炎(MAP)和重症急性胰腺炎(SAP)两类,多数急性胰腺炎患者预后良好,其总体病死率为5%~10%[2-3]。胰腺以及胰腺

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