弥散峰度成像评估鼻咽癌放疗后颞叶灰白质微观结构变化的研究

发布时间：2018-01-04 03:08

本文关键词：弥散峰度成像评估鼻咽癌放疗后颞叶灰白质微观结构变化的研究　出处：《中国医学计算机成像杂志》2017年02期 　论文类型：期刊论文

【摘要】：目的:探讨弥散峰度成像(DKI)在检测鼻咽癌放疗后颞叶灰质与白质微观结构变化中的诊断价值。方法:本研究共纳入60例鼻咽癌患者和20例健康志愿者。根据放疗完成至DKI检查时间间隔将60例鼻咽癌患者分为三组,每组20人:A组(1周)、B组(6个月)和C组(12个月),所有鼻咽癌患者和对照组志愿者常规磁共振检查均未发现明显异常。由2名放射科专家在协商一致情况下手动勾画颞叶灰质和白质感兴趣区,计算感兴趣区MD、MK和FA值,并进行统计学分析。结果:与正常对照组相比,放疗结束后1周颞叶灰质与白质的MK值增加,放疗结束后6个月和12个月时MK值降低。放疗结束后1周MD值高于正常对照组,但放疗后6个月和12个月时MD值接近正常。结论:DKI能够动态监测鼻咽癌放疗后不同时期颞叶灰白质微观结构变化,定量测量MD和MK有助于早期发现常规磁共振无法显示的隐匿性损伤,为临床早期诊断和早期干预提供更客观的影像学证据。
[Abstract]:Objective: to investigate the diffusion kurtosis imaging (DKI). Diagnostic value of microstructural changes in temporal lobe gray matter and white matter after radiotherapy for nasopharyngeal carcinoma. Methods:. In this study, 60 patients with nasopharyngeal carcinoma and 20 healthy volunteers were divided into three groups according to the interval between radiotherapy and DKI examination. Group B (6 months) and group C (12 months). No obvious abnormality was found in routine MRI examination of all patients with nasopharyngeal carcinoma and control group. 2 radiologists manually delineated gray matter and white matter areas of interest in temporal lobe by consensus. Results: compared with the normal control group, the MK values of temporal lobe gray matter and white matter increased 1 week after radiotherapy. MK decreased at 6 months and 12 months after radiotherapy, and MD value was higher than that in normal control group at 1 week after radiotherapy. But the MD value was close to normal at 6 and 12 months after radiotherapy. Conclusion: DKI can dynamically monitor the microstructure of gray matter in temporal lobe of nasopharyngeal carcinoma at different time after radiotherapy. Quantitative measurement of MD and MK is helpful for early detection of occult injuries that can not be demonstrated by conventional MRI and provides more objective imaging evidence for early clinical diagnosis and early intervention.
【作者单位】：上海市第六人民医院南院放射科;上海市第六人民医院放射科;
【基金】：国家自然基金NO.81471656 上海市自然基金NO.14ZR1432100 上海市人才发展基金:NO.201555
【分类号】：R445.2;R739.63
【正文快照】： 中国医学计算机成像杂志,2017,23:124-130Chin Comput Med Imag,2017,23:124-1301Department of Radiology,Shanghai Sixth Hospital South Branch,Shanghai Jiaotong University2Department of Radiology,Shanghai Sixth Hospital,Shanghai JiaotongUniversityAddress:Fengxi

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