原发性闭角型青光眼患者初级视觉皮层功能连接的静息态fMRI研究

发布时间：2018-01-04 11:11

本文关键词：原发性闭角型青光眼患者初级视觉皮层功能连接的静息态fMRI研究　出处：《临床放射学杂志》2017年04期 　论文类型：期刊论文

【摘要】：目的应用静息态功能磁共振成像(rs-fMRI)技术研究原发性闭角型青光眼(PACG)患者初级视觉皮层(PVC)功能连接的变化情况。方法选取临床确诊的PACG患者(PACG组)及与之年龄、性别相匹配的健康对照组(HC组)行3T磁共振T_1结构像及功能像扫描,最终纳入PACG组和HC组各25例进行rs-fMRI分析。磁共振数据经预处理后,以PVC中心区作为种子点,计算其与全脑体素时间序列的相关性并比较组间静息态功能连接的差异,并分析患者组显著差异脑区功能连接系数与临床变量的相关性。结果与HC组相比,PACG组左侧距状皮层(BA18)、左侧舌回(BA18)、右侧楔叶(BA18)、右侧后扣带回、右侧小脑前叶与PVC之间的功能连接减低,PVC功能连接增强的脑区包括左侧颞上回、右侧海马、右侧顶下小叶、双侧岛叶、双侧Extra-nuclear gyrus及双侧壳核(P㩳0.01,Alphasim校正)。PVC与左侧颞上回、右侧顶下小叶间增强的功能连接与视力(VA)呈正相关。结论PACG患者PVC区存在与高级视觉皮层和视觉外脑区功能连接下降,与视力相关的功能连接代偿性增强,提示PVC功能连接异常在PACG疾病进展中起重要作用。
[Abstract]:The purpose of application of resting state functional magnetic resonance imaging (rs-fMRI) of primary angle closure glaucoma (PACG) patients with primary visual cortex (PVC) changes of functional connectivity. Methods the clinical diagnosis of PACG patients (PACG group) and the age and gender matched healthy control group (group HC) 3T magnetic resonance T_1 like structure and functional imaging, and ultimately included in the PACG group and HC group with 25 cases in each group were analyzed by rs-fMRI. MRI data after the pretreatment, PVC center as the seed point, and calculate the whole brain voxel time series correlation and comparison between group differences in resting state functional connectivity. And analyze the correlation function of the patients with significant brain connection coefficient and clinical variables. Results compared with HC group, PACG group, left calcarine cortex (BA18), left lingual gyrus (BA18), cuneus (BA18), right posterior cingulate, right between the anterior lobe of cerebellum and PVC functional connectivity Decreased brain PVC increased functional connectivity including left superior temporal gyrus, right hippocampus, right inferior parietal lobule, bilateral insula, bilateral Extra-nuclear gyrus and bilateral putamen (P? 0.01, Alphasim correction).PVC and left superior temporal gyrus, right inferior parietal lobule enhance functional connectivity and visual acuity (VA) was positively correlated. Conclusion PACG patients PVC connected with advanced visual cortex and visual brain areas with decreased function of vision related functional connectivity and compensatory increase of PVC functional connectivity in the progression of PACG play an important role.

【作者单位】：南昌大学第一附属医院影像科;南昌大学第一临床医学院;
【基金】：国家自然基金项目资助(编号:81360219)
【分类号】：R445.2;R775
【正文快照】： 青光眼是一种进行性视神经病,主要特点为视网膜神经节细胞(retinal ganglion ceils,RGCs)进行性丢失和视神经损害,最终导致视野缺失,甚至失明,是导致失明的主要原因。大量文献报道,RGCs的进行性丢失被认为在青光眼发病机制中起关键作用[1~3]。Gupta等[4]首次发现青光眼氏损害

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