2015年安徽医科大学第一附属医院临床分离菌耐药性监测

发布时间：2018-01-04 19:00

本文关键词：2015年安徽医科大学第一附属医院临床分离菌耐药性监测　出处：《中国感染与化疗杂志》2017年04期 　论文类型：期刊论文

【摘要】：目的了解安徽医科大学第一附属医院2015年临床分离菌的分布和耐药情况。方法采用纸片扩散法和自动化仪器进行抗菌药物敏感性试验。结果 2015年该院临床分离菌共5 524株,其中革兰阴性细菌3 882株,革兰阳性细菌1 642株,分别占临床分离菌70.3%和29.7%。葡萄球菌属中耐甲氧西林金黄色葡萄球菌(MRSA)和耐甲氧西林凝固酶阴性葡萄球菌(MRCNS)的检出率分别为57.6%和83.0%。葡萄球菌属中未发现对万古霉素和利奈唑胺不敏感株。肠球菌属中粪肠球菌和屎肠球菌的检出率分别为46.1%和46.8%,并两者均发现万古霉素和利奈唑胺不敏感株。大肠埃希菌、克雷伯菌属和奇异变形杆菌产超广谱β内酰胺酶(ESBL)菌株的检出率分别为62.0%,32.2%和18.8%。肠杆菌科细菌对碳青霉烯类保持较高的敏感性,对厄他培南、亚胺培南和美罗培南的耐药率均低于22%。结论该院的细菌耐药性仍对临床的抗菌治疗构成严重威胁,应加强耐药性监测并合理规范抗生素的使用。
[Abstract]:Objective to investigate the distribution and drug resistance of clinical isolates in 2015 of the First Affiliated Hospital of Medical University Of Anhui. Methods using the disk diffusion method and automatic instrument for antimicrobial susceptibility test results. In 2015 the hospital clinical isolates of 5524 strains, including 3882 strains of gram negative bacteria, gram positive bacteria accounted for 1642 strains of methicillin resistant Staphylococcus aureus resistant clinical isolates of Staphylococcus in 70.3% and 29.7%. (MRSA) and methicillin resistant coagulase negative staphylococcus (MRCNS) detection rates were 57.6% and 83.0%. in Staphylococcus was not found to be sensitive to vancomycin and linezolid. Strains of Enterococcus faecalis and Enterococcus faecium respectively 46.1% and 46.8%, and both were found not sensitive to vancomycin and linezolid. Strains of Escherichia coli, Klebsiella pneumoniae and Proteus ESBLs (ESBL) strain rates respectively were 62%, 32.2% and 18.8%. of Enterobacteriaceae to carbapenem sensitive to ertapenem, bacterial resistance, resistance to imipenem and meropenem were lower than 22%. conclusion the hospital still poses a serious threat to the clinical antibiotic treatment, should strengthen the monitoring of drug resistance and rational use specification for antibiotics.

【作者单位】：安徽医科大学第一附属医院检验科;
【基金】：国家自然科学基金项目(81171618)
【分类号】：R446.5
【正文快照】： 作者单位:安徽医科大学第一附属医院检验科,合肥230022。细菌耐药,尤其是细菌的多重耐药、广泛耐药、和全耐药现象愈加严重,给临床的抗感染治疗带来了严峻的挑战。合理使用抗生素,减少耐药细菌的出现十分重要。现将安徽医科大学第一附属医院2015年临床分离菌的分布以及主要细

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