抑郁性失眠多导睡眠图研究

发布时间：2018-01-05 11:26

  本文关键词：抑郁性失眠多导睡眠图研究　出处：《浙江大学》2017年硕士论文　论文类型：学位论文

  更多相关文章： 抑郁性失眠 原发性失眠 多导睡眠图

【摘要】：背景:抑郁性失眠和原发性失眠临床表现相似,两者容易混淆,依靠症状学作出的诊断容易发生误诊。抑郁症患者多导睡眠图(Polysomnography,PSG)异常改变被认为是一种生物标记。PSG在抑郁性失眠和原发性失眠的鉴别诊断中是否有价值仍不清楚。目的:研究抑郁性失眠多导睡眠图的特点,为抑郁症诊断提供生物学指标。方法:本研究纳入符合国际疾病分类(第10版)(International Classification of Diseases 10,ICD-10)抑郁障碍诊断标准的86名患者,选择同时符合失眠(匹兹堡睡眠量表评分6分,失眠病程1个月,每周至少3天存在失眠症状)诊断标准的患者52例作为抑郁性失眠组;纳入符合原发性失眠患者38例为原发性失眠组。在消除药物对PSG的影响后,记录两组患者首夜PSG临床常用指标,采用卡方检验和t检验分析抑郁症性失眠与原发性失眠患者的PSG的差异。结果:与原发性失眠相比,两组在(1)睡眠进程:睡眠潜伏期[(35.93±10.69)分钟vs(64.74±19.65)分钟)差异有显著性(t=8.93,t检验,P0.01);总睡眠时间、睡眠效率、N2期睡眠潜伏期、入睡后醒觉时间、5min醒觉次数、微觉醒次数,差异无显著性(P0.05)。(2)睡眠结构:N1次数分别为(9.40±2.62)和(10.63±3.07),有差异(t=2.04,t检验,P=0.04),而两组的觉睡比、N1睡眠比、N2睡眠比、N2次数、N3睡眠比、N3次数差异均无显著性(P0.05)。(3)快动眼睡眠潜伏期分别为(83.23±18.64)分钟和(188.71±49.44)分钟,差异有显著性(t=14.01,t检验,P0.01);快动眼睡眠时间比分别为(9.68±2.31)vs(7.43±2.84),差异有显著性(t=4.14,t检验,P0.01);但两组快动眼睡眠次数差异无显著性(P0.05)。结论:抑郁性失眠患者与原发性失眠患者PSG指标有差异,如睡眠潜伏期和快动眼睡眠潜伏期以及快动眼睡眠时间比差异显著,PSG的这些特点可以作为两种失眠鉴别的辅助手段。
[Abstract]:Background: depressive insomnia and similar primary insomnia clinical manifestations, both easy to confuse, rely on the diagnosis of symptoms made to misdiagnosis. Polysomnography in patients with depression (Figure Polysomnography, PSG) abnormality is considered whether a biomarker.PSG value in depressive insomnia and the differential diagnosis of primary insomnia still unclear. Objective: To study the characteristics of depressive insomnia polysomnography, provide biological indices for diagnosis of depression. Methods: This study included in the international classification of diseases (Tenth Edition) (International Classification of Diseases 10, ICD-10) in 86 patients with a diagnosis of depression disorder standard, at the same time with the choice of Pittsburgh (the amount of sleep insomnia table 6 scores, sleep duration of 1 months, at least 3 days a week there are 52 cases of insomnia symptoms) as the diagnostic criteria of depressive insomnia group patients; patients with primary insomnia in 38 cases 涓哄師鍙戞，

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