血清淀粉样蛋白A联合C反应蛋白对儿童甲型流感早期诊断价值的评价

发布时间：2018-01-05 19:14

本文关键词：血清淀粉样蛋白A联合C反应蛋白对儿童甲型流感早期诊断价值的评价　出处：《实用医学杂志》2017年14期 　论文类型：期刊论文

【摘要】：目的探讨血清淀粉样蛋白A(SAA)、C反应蛋白(CRP)和SAA/CRP比值在早期诊断儿童甲型流感的临床应用价值。方法选取2016年4-6月诊断为甲型流感的139例患儿为研究对象,另选取健康儿童278例为对照组,检测两组儿童SAA、CRP、SAA/CRP比值、白细胞(WBC)等指标水平,采用受试者工作特征曲线(ROC)分析各指标对甲流的诊断价值。结果甲型流感患儿SAA、CRP水平以及SAA/CRP比值显著高于健康对照组(P0.001),其中SAA、SAA/CRP比值的ROC曲线下面积(AUC)均0.7,且差异有统计学意义(P0.001)。当SAA为10.500 mg/L,敏感度为85.5%,特异度96.8%;当SAA/CRP比值为6.165,敏感度为55.4%,特异度91.4%。结论 SAA与CRP联合检测对早期诊断儿童甲型流感具有一定的价值,其中SAA的价值最高。
[Abstract]:Objective to study the serum amyloid Agna. C-reactive protein (CRP). The clinical application value of SAA/CRP ratio in early diagnosis of influenza A in children was studied. Methods 139 children with influenza A diagnosed from April to June in 2016 were selected as study subjects. Two hundred and eighty-eight healthy children were selected as control group. The serum levels of SAA- CRPSAA / CRP ratio and WBC- WBCwere measured in two groups. The diagnostic value of each index in the diagnosis of swine flu was analyzed by using the operating characteristic curve of the subjects. Results SAA was used in children with influenza A. The level of CRP and the ratio of SAA/CRP were significantly higher than those of the healthy control group (P 0.001). The area under the ROC curve of SAA A / R ratio was 0.7. When the SAA was 10.500 mg / L, the sensitivity was 85.5 and the specificity was 96.8; When the SAA/CRP ratio is 6.165, the sensitivity is 55.4 and the specificity is 91.4. Conclusion the combined detection of SAA and CRP is valuable for early diagnosis of influenza A in children. The value of SAA is the highest.
【作者单位】：广州市越秀区儿童医院呼吸科;
【基金】：广东省医学科研基金(编号:B2014351) 广州市医药卫生科技项目(编号:2009-YB-177)
【分类号】：R446.1;R725.1
【正文快照】： 全球有详细记载的甲型流感(甲流)大流行共有6次[1],在我国,甲流是需要密切监测的突发公共卫生事件之一,而且甲流的重症病例发生率、病死率以及并发症发生率均远高于普通感冒[2]。虽然临床上对流感样病例强调在发病48 h内尽早开始抗流感病毒药物治疗,但相对于成人病例,儿童甲流

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