儿科重症监护室多重耐药革兰阴性菌感染危险因素

发布时间：2018-01-07 09:23

本文关键词：儿科重症监护室多重耐药革兰阴性菌感染危险因素　出处：《中国消毒学杂志》2017年10期 　论文类型：期刊论文

【摘要】：目的探讨儿科重症监护室(PICU)多重耐药革兰阴性菌(MDR-GNB)感染的危险因素,为有效防控提供参考。方法采用回顾性分析方法,对某医院PICU住院期间发生的革兰阴性菌感染病例进行调查。通过细菌培养、药敏试验结果以及logistics回归分析,对多重耐药革兰阴性菌感染的危险因素进行分析。结果 133例调查对象中,MDR-GNB组62人,非MDR-GNB组71人。回归分析发现,持续性机械通气、院内感染、烧伤或电击伤以及前期不合理的抗菌药物治疗为MDR-GNB感染的危险因素。MDR-GNB感染患儿住院时间(t=4.3,P=0.000)和住PICU(t=5.1,P=0.000)时间均显著延长,死亡率明显高于非MDR-GNB组(χ2=4.1,P=0.047)。结论 PICU内MDR-GNB感染患儿住院时间延长,死亡率增加,预后差,应针对危险因素制定干预措施。
[Abstract]:Objective to investigate the pediatric intensive care unit (PICU) multi drug resistant gram negative bacteria (MDR-GNB) infection risk factors, to provide reference for the effective prevention and control. Methods a retrospective analysis of the cases occurred during leather gram negative bacteria infection of hospitalized PICU in a hospital. Through the analysis of the results of bacterial culture and drug sensitivity test of logistics regression of multidrug-resistant gram negative bacteria infection risk factors of leather were analyzed. Results 133 patients surveyed, 62 people in the MDR-GNB group and non MDR-GNB group 71. Regression analysis showed that continuous mechanical ventilation, nosocomial infection, antibiotic burns or electrical injury early and unreasonable treatment for risk factors of.MDR-GNB MDR-GNB infection with the length of time (t=4.3, P=0.000) and PICU (t=5.1, P=0.000) time was significantly longer, the mortality rate was significantly higher than non MDR-GNB group (2=4.1, P=0.047). Conclusion PICU infection in MDR-GNB The duration of hospitalization, the increase of mortality, poor prognosis, and intervention measures should be formulated for the risk factors.

【作者单位】：温州医科大学附属第二医院育英儿童医院;
【分类号】：R446.5
【正文快照】： 随着抗菌药物的广泛应用,耐药细菌的出现成为临床患者感染的主要威胁。多重耐药革兰阴性菌(multidrug-resistant gram-negative bacteria,MDR-GNB)[1],主要包括铜绿假单胞菌、嗜麦芽窄食单胞菌、鲍曼不动杆菌以及耐碳青霉烯类肠杆菌科细菌,其引起的感染是当前感染诊疗和研究的

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