宫颈癌患者磁共振体素不相干运动相关参数变化及意义

发布时间：2018-01-09 18:23

本文关键词：宫颈癌患者磁共振体素不相干运动相关参数变化及意义　出处：《山东医药》2017年40期 　论文类型：期刊论文

【摘要】：目的探讨宫颈癌患者3.0T磁共振体素不相干运动(IVIM)相关参数变化及其诊断价值。方法选择宫颈癌患者29例作为观察组,体检健康女性24例作为对照组。两组均进行常规MRI及IVIM扫描,IVIM扫描采用13个b值,所得原始数据采用双指数模型进行分析,记录并比较两组标准表观扩散系数(标准ADC)、慢ADC、快ADC及灌注相关体积分数(f),采用受试者工作特征曲线(ROC曲线)评价各参数对宫颈癌的诊断效能。结果观察组与对照组标准ADC分别为(0.90±0.15)×10~(-3)、(1.15±0.23)×10~(-3)mm~2/s,慢ADC分别为(0.70±0.12)×10~(-3)、(0.97±0.21)×10~(-3)mm~2/s,快ADC分别为(6.66±2.02)×10~(-3)、(5.30±1.64)×10~(-3)mm~2/s,f分别为0.29±0.09、0.45±0.11;观察组标准ADC、慢ADC、f均低于对照组(P均0.05),两组快ADC比较差异无统计学意义(P0.05)。标准ADC、慢ADC、快ADC及f诊断宫颈癌的曲线下面积分别为0.79、0.86、0.32、0.84,以慢ADC最大,其临界值为0.89×10~(-3)mm~2/s时诊断宫颈癌的敏感性为70%、特异性为90%。结论宫颈癌患者IVIM相关参数标准ADC、慢ADC及f均降低,上述参数检测有助于宫颈癌的诊断。
[Abstract]:Objective to investigate the changes and diagnostic value of 3. 0T magnetic resonance voxel (VMI) related parameters in patients with cervical cancer. Methods 29 patients with cervical cancer were selected as the observation group. 24 healthy women were used as control group. Both groups underwent routine MRI and IVIM scanning using 13 b values. The original data were analyzed by double index model. Two groups of standard apparent diffusion coefficients (standard ADCA, slow ADCC, fast ADC and perfusion correlation volume fraction F) were recorded and compared. The diagnostic efficacy of each parameter for cervical cancer was evaluated by using the operating characteristic curve (ROC curve). Results the standard ADC of the observation group and the control group was 0.90 卤0.15 脳 10 ~ (-1) ~ (-3) respectively. The slow ADC was 0.70 卤0.12 脳 10 ~ (-3) 脳 10 ~ (-3) / s (n = 1.15 卤0.23) 脳 10 ~ (-3) / s. The ADC was 0.97 卤0.21) 脳 10 ~ (-1) mm ~ (-3) / s, and the fast ADC was 6.66 卤2.02 脳 10 ~ (-3)). 5.30 卤1.64) 脳 10 ~ (-3) / m ~ (-2) / s ~ (-1) F = 0.29 卤0.09 卤0.45 卤0.11, respectively; The standard ADCand slow ADCF in the observation group were lower than those in the control group (P < 0.05). There was no significant difference in fast ADC between the two groups (P < 0.05). The area under the curve of fast ADC and f for diagnosis of cervical cancer was 0.79 ~ 0.86 ~ 0.32 ~ 0.84, respectively. Slow ADC was the largest. When the critical value was 0.89 脳 10 ~ (-3) mm ~ (-1) / s, the sensitivity of diagnosis of cervical cancer was 70 and the specificity was 90. Conclusion the IVIM related parameter standard ADC for cervical cancer patients. Slow ADC and f were decreased, and the above parameters were helpful for the diagnosis of cervical cancer.
【作者单位】：武汉大学中南医院;荆门市第一人民医院;
【分类号】：R445.2;R737.33
【正文快照】： 目前磁共振检查广泛用于宫颈癌的诊断,其中扩散加权成像(DWI)在宫颈癌的诊断、分期以及预后评估方面均具有较高的应用价值[1,2]。DWI中最常用的参数表观扩散系数(ADC)可在一定程度上反映组织内水分子扩散程度,但传统单一指数模型具有一定局限性,例如毛细微循环无规律方向灌注

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