超声造影时间-强度曲线对急性肾损伤的诊断价值

发布时间：2018-01-11 00:27

本文关键词：超声造影时间-强度曲线对急性肾损伤的诊断价值　出处：《中国超声医学杂志》2017年09期 　论文类型：期刊论文

【摘要】：目的探讨急性肾损伤早期肾实质血流灌注的变化规律。方法将40只雄性新西兰大白兔随机分为5组,每组8只,经耳缘静脉注射顺铂建立急性肾损伤模型,于造模后6、12、24、36h及48h进行双肾超声造影检查及测血SCr,分析不同时间点造影动态图像,获取TIC曲线及相关参数。以SCr较基础值升高1.5倍或以上为AKI诊断标准,使用SPSS 22.0及Medcalc对数据进行分析,以P0.05为差异具有统计学意义。取兔双肾做常规石蜡切片,HE染色光镜下观察。结果 T24、T36组及T48组实验兔均发生了AKI。与建模前相比,建模后T12、T24、T36组及T48组皮质RT,T24、T36组及T48组皮质PI、T_(1/2)、mTT及TTP,T36组及T48组皮质AUC及WIS均发生了显著改变(P0.05),髓质各造影参数均未发生显著改变。部分造影指标对AKI诊断效能较佳,灵敏度较高。结论超声造影可良好的反映AKI早期肾皮质血流灌注的改变,皮质RT可较SCr早期发现AKI,且具有较好的诊断效能。
[Abstract]:Objective to investigate the changes of renal parenchyma perfusion in the early stage of acute renal injury. Methods 40 male New Zealand white rabbits were randomly divided into 5 groups, 8 rabbits in each group, and the acute renal injury model was established by intravenous injection of cisplatin through the ear margin. Bilateral renal ultrasonography was performed at 6: 12 and 24 hours after modeling for 36 hours and 48 hours, and blood SCR was measured, and dynamic imaging at different time points was analyzed. The TIC curve and related parameters were obtained. The AKI diagnostic criteria were that the SCr was 1.5 times higher than the basic value. The data were analyzed by SPSS 22.0 and Medcalc. Take P05 as the difference has the statistical significance. Take the rabbit double kidney to do the routine paraffin section to observe under the light microscope. Results T24. AKIs were found in both T36 and T48 groups. Compared with those before modeling, the cortex Pi of T12 T24 T36 group and T48 group were compared with that of T48 group and T48 group. There were significant changes in cortical AUC and WIS in the TTP T36 group and TTP T36 group and T48 group (P 0.05). There were no significant changes in the parameters of medullary angiography. Some of the parameters were more effective and sensitive in the diagnosis of AKI. Conclusion Contrast-enhanced ultrasonography can well reflect the changes of renal cortical blood perfusion in the early stage of AKI. Cortex RT can detect AKI earlier than SCr, and has better diagnostic efficacy.
【作者单位】：解放军第306医院超声医学科;
【分类号】：R445.1;R692.5
【正文快照】： 结果T24、T36组及T48组实验兔均发生了AKI。与建模前相比,建模后T12、T24、T36组及T48组皮质RT,T24、T36组及T48组皮质PI、T1/2、mTT及TTP,T36组及T48组皮质AUC及WIS均发生了显著改变(P0.05),髓质各造影参数均未发生显著改变。部分造影指标对AKI诊断效能较佳,灵敏度较高。结

【相似文献】