微阵列检测技术在早期胚胎停育中的应用

发布时间：2018-01-12 03:12

本文关键词：微阵列检测技术在早期胚胎停育中的应用　出处：《实用医学杂志》2017年21期 　论文类型：期刊论文

【摘要】：目的将微阵列检测技术应用于早期胚胎停育患者流产组织染色体分析,探讨其在胚胎停育遗传学病因分析中的应用价值。方法收集273例确诊为胚胎停育并行人工流产患者的流产组织,进行微阵列检测。结果 273例早期胚胎停育患者中,结果阳性者占41.4%。染色体数目异常61例,占22.34%;染色体结构异常43例,包括末端缺失/重复和内部微缺失和微重复,占15.75%;嵌合体9例,占3.3%。结论微阵列检测应用于胚胎停育患者流产组织染色体分析具有较强的特异性,能提供更全面的信息,在遗传学病因诊断和再生育风险评估中有较好的应用价值。
[Abstract]:Objective to apply the technique of microarray detection to the analysis of chromosomes in abortive tissues of patients with early embryo arrest. To explore its application value in etiological analysis of fetal arrest. Methods 273 cases of abortive tissue were collected. Results among 273 cases of early embryo termination, 41.4 cases were positive, and 61 cases (22.34%) had abnormal chromosome number, and the number of chromosomes was abnormal in 61 cases (22.34%), and the number of chromosomes was abnormal in 61 cases (22.34%). Chromosomal structural abnormalities were found in 43 cases, including terminal deletion / duplication and internal microdeletion and microduplication, accounting for 15.75%. Conclusion the application of microarray detection in chromosome analysis of abortive tissues in patients with fetal arrest has strong specificity and can provide more comprehensive information. It has good application value in genetic etiology diagnosis and risk assessment of re-fertility.
【作者单位】：华中科技大学同济医学院附属武汉儿童医院(武汉市妇幼保健院)妇产科;华中科技大学同济医学院附属武汉儿童医院(武汉市妇幼保健院)科教科;
【基金】：武汉市卫计委医疗卫生科研项目(编号:WG15C10)
【分类号】：R440;R714.2
【正文快照】： 胚胎停育是指妊娠早期胚胎因某种原因所致的发育停止,其发病率约为1%,占临床妊娠的15%~20%[1]。近年来,随着环境问题的突出及二胎政策的开放,临床上观察到早期胚胎停育的发病率呈逐年上升趋势,严重影响妇女的身心健康。胚胎停育的发病原因非常复杂,其发病机制至今尚不十分清楚

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