49946株常见病原菌对左旋氧氟沙星耐药性变化分析

发布时间：2018-01-12 05:23

本文关键词：49946株常见病原菌对左旋氧氟沙星耐药性变化分析　出处：《现代预防医学》2017年16期 　论文类型：期刊论文

【摘要】：目的了解常见病原菌对左旋氧氟沙星的耐药性变化趋势,为临床合理应用喹诺酮类药物提供参考。方法收集郑州大学第一附属医院2011年1月-2016年6月细菌室分离的49 946株不重复菌株,进行回顾性分析,探讨常见病原菌对左旋氧氟沙星的耐药性变迁。结果金黄色葡萄球菌和凝固酶阴性的葡萄球菌是革兰阳性菌感染的主要病原菌(约52.00%),大肠埃希菌、肺炎克雷伯菌是最常见的肠杆菌科细菌(占整个阴性杆菌45.10%),铜绿假单胞菌、鲍曼不动杆菌在非发酵菌感染中占绝对优势(占整个阴性杆菌28.10%)。6年间几种常见病原菌对左旋氧氟沙星总耐药率为53.66%。大肠埃希菌耐药性最严重,为70.11%,其次为鲍曼不动杆菌,耐药率60.86%;金葡菌耐药性呈显著下降趋势,由2011年61.55%降至2016年的41.12%,凝固酶阴性的葡萄球菌始终保持在55%以上;肺炎克雷伯菌与铜绿假单胞菌对左旋氧氟沙星耐药率相对较低,其敏感性均保持在60%左右。结论大肠埃希菌、鲍曼不动杆菌对于喹诺酮类药物具有广泛耐药性,临床应加强此类菌株感染治疗的指导与监测。
[Abstract]:Objective to investigate the trend of drug resistance of common pathogens to levofloxacin. Methods 49,946 non-repetitive strains isolated from the bacterial laboratory of the first affiliated Hospital of Zhengzhou University from January 2011 to June 2016 were collected. To carry out retrospective analysis. Results Staphylococcus aureus and coagulase-negative staphylococcus were the main pathogens of Gram-positive bacteria infection (about 52.00). Escherichia coli, Klebsiella pneumoniae is the most common Enterobacteriaceae bacteria (accounting for the entire negative bacilli 45.10%, Pseudomonas aeruginosa). Acinetobacter baumannii is dominant in non-fermentative bacteria infection (28. 10 percent of all negative bacilli). The total resistance rate of several common pathogens to levofloxacin was 53.66. Escherichia coli resistance was the most serious. The drug resistance rate of Acinetobacter baumannii was 60.86. Drug resistance of Staphylococcus aureus decreased significantly from 61.55% on 2011 to 41. 12 on 2016. Coagulase-negative staphylococcus remained above 55%. The susceptibility of Klebsiella pneumoniae and Pseudomonas aeruginosa to levofloxacin was relatively low, and its sensitivity was about 60%. Conclusion Escherichia coli. Acinetobacter baumannii has extensive resistance to quinolones.
【作者单位】：郑州大学第一附属医院检验科;
【基金】：河南省科技发展计划项目,(162102310509)
【分类号】：R446.5
【正文快照】： 喹诺酮类药物是一种广谱抗菌药物,在临床抗感染中应用较为广泛。喹诺酮类药物中,使用最为广泛的是左旋氧氟沙星,相比氧氟沙星,左旋氧氟沙星抗菌谱广,对大多数肠杆菌科细菌、非发酵菌以及流感嗜血杆菌等革兰阴性细菌有较强的抗菌活性,故在世界范围内、各级医院内广泛应用。研究

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