联合静息态与DTI探究AD患者大脑的早期改变

发布时间：2018-01-12 10:03

本文关键词：联合静息态与DTI探究AD患者大脑的早期改变　出处：《中国CT和MRI杂志》2017年02期 　论文类型：期刊论文

【摘要】：目的通过探究阿尔茨海默病(AD)的ALFF值差异相关脑区的FA值,为AD的早期诊断提供功能与分子影像学依据。方法采用西门子Trio 3.0T磁共振对17例AD病人及17例对照组被试进行静息态fmri、DTI检查。对静息态、DTI原始数据进行预处理,得到ALFF图和FA图,并进行组间独立双样本t检验,得到具有统计学意义的差异脑区,做成mask用于FA图的统计,然后进行组间独立样本t检验。结果AD组和健康对照组相比,AD组患者ALFF值在右侧后扣带回、双侧中央前回及左侧额中回等脑区降低,在左侧丘脑、右侧海马旁回及右侧颞上回等脑区增高,同时这些脑区的FA值均增高。结论阿尔茨海默病患者与健康对照组相比,ALFF值异常的脑区,如右侧后扣带回、左侧额中回、右侧颞下回等默认网络脑区,FA值也同时存在异常,说明AD患者功能存在异常的脑区的微观结构也同时存在异常,这为早期客观有效地诊断阿尔茨海默病提供了可能。
[Abstract]:Objective to explore Alzheimer's disease (AD) the ALFF value of brain areas related to differences in FA value, functional and molecular imaging for early diagnosis of AD. On the basis of study method of SIEMENS Trio 3.0T MRI in 17 AD patients and 17 cases of control group were tested by the resting state fMRI, DTI examination. The resting state, DTI the original data were preprocessed by ALFF and FA charts, and two groups of independent samples t test, the difference was statistically significant by brain regions, made mask FA for statistical graphs, then groups of independent sample t test. Results compared to AD group and healthy control group, AD group of patients with ALFF value right posterior cingulate, bilateral lower precentral gyrus and left middle frontal gyrus, the left thalamus increased, right parahippocampal gyrus and right middle temporal gyrus, and these areas of the brain FA values were increased. Compared with the conclusion of Alzheimer's disease patients and healthy control group, ALFF The value of abnormal brain regions, such as the right posterior cingulate gyrus, left middle frontal gyrus, right inferior temporal gyrus and other brain regions also default network, abnormal FA value, microcosmic structure exists abnormal brain function in patients with AD are also abnormal, which provides the possibility for the early diagnosis of Alzheimer's disease objectively and effectively.

【作者单位】：福建医科大学福总临床医学院影像科;南京军区福州总医院医学影像中心;
【基金】：福建省科技计划重点项目(NO.2012Y0057)
【分类号】：R445.2;R749.16
【正文快照】： 阿尔兹海默病(Alzheimer's disease,AD)是一种进行性不可逆的神经脑退行性病变,以记忆力及认知功能减退甚至行为改变为特征,个人生活自理能力和情感人格基本丧失[1]。其临床诊断主要依赖临床体检和神经心理学测试,想要进行确诊,仍需病理学检查,目前AD的唯一金标准仍是大量神经

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