420例成人流感样患者呼吸道病毒感染及其主要病原体分布

发布时间：2018-01-12 12:12

本文关键词：420例成人流感样患者呼吸道病毒感染及其主要病原体分布　出处：《现代预防医学》2017年20期 　论文类型：期刊论文

【摘要】：目的了解发热呼吸道病毒在成人流感样患者中的病原学分布及其相应的临床表现特点。方法以南方医科大学珠江医院2009年11月-2014年10月收治的流感样疾病成人患者为研究对象,不符合流感样疾病但出现部分流感样疾病临床症状的成人患者为对照,采用q RT-PCR方法检测临床上常见的10种(18个亚型)呼吸道病原体。结果 420例流感样患者中,188例患者检测出201个阳性病毒反应,其中多重感染12例,患者阳性率为44.8%,病毒检出率为47.9%;对照组115例中仅3例阳性,病毒检出率为2.6%。所检病毒以流感病毒为主,为51.2%(103/201);其次为鼻病毒和冠状病毒。各年龄段患者间病毒感染率无统计学差异,不同年龄段患者间所感染的病毒种类存在统计学差异,流感病毒主要感染人群为18~30岁年龄段,冠状病毒和鼻病毒分别以51~70岁和51~90岁年龄段患者最多。结论病毒感染是引起成人流感样呼吸道症状的主要病原体,并以季节性流感病毒为优势病毒,其他呼吸道病毒散发,不同病毒种类在各个年龄段流感样疾病患者中感染率存在明显差异。
[Abstract]:Objective to investigate the etiological distribution of febrile respiratory tract virus (FRTV) in adult influenza like patients and its clinical features. Methods from November 2009 to October 2014, Zhujiang Hospital, Southern Medical University, was admitted to our hospital. Ten percent of adult patients with influenza like disease were studied. Adult patients who did not conform to influenza-like diseases but developed some of the clinical symptoms of influenza-like diseases served as controls. Ten common respiratory pathogens (18 subtypes) were detected by Q RT-PCR method. 201 positive virus reactions were detected in 188 patients, of which 12 were multiple infections, the positive rate was 44.8 and the detection rate of virus was 47.9. In the control group, only 3 cases were positive, and the positive rate of virus was 2.6%. The main virus detected was influenza virus (51.2% 10 / 201). The next is rhinovirus and coronavirus. There is no statistical difference in viral infection rate among patients of different age groups, but there is statistical difference in the types of virus infection among patients of different age groups. Influenza virus is mainly infected by the 180-30 age group. Coronavirus and rhinovirus were the most common in patients aged 51 ~ 70 years and 51 ~ 90 years old respectively. Conclusion viral infection is the main pathogen of influenza-like respiratory symptoms in adults. With seasonal influenza virus as the dominant virus and other respiratory viruses distributed, the infection rate of different kinds of viruses was significantly different among patients with influenza like diseases of all ages.
【作者单位】：南方医科大学珠江医院检验医学部;
【基金】：国家科技重大专项(2014ZX10004005) 广东省自然科学基金(2015A030313268) 广东省科技计划(2014A020212492)
【分类号】：R440;R511.7
【正文快照】： 急性呼吸道感染是导致人类发病和死亡的一个重要原因,研究表明,70%~80%的急性呼吸道感染都是由病毒感染所致,其最大危险在于某些病毒具有潜在引发局部范围甚至世界大流行的可能,如1997年在香港肆虐的禽流感、2003年SARS的暴发以及2009年甲型H1N1流感在全国范围的流行。本研究

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