反社会人格障碍患者说谎状态下的功能磁共振研究

发布时间：2018-01-12 22:23

本文关键词：反社会人格障碍患者说谎状态下的功能磁共振研究　出处：《广东医学》2017年20期 　论文类型：期刊论文

【摘要】：目的探讨有病理性说谎的反社会人格障碍(APD)患者,在执行说谎任务时脑区激活模式及对揭示疾病功能机制的重要意义。方法对20例有欺骗行为的APD患者(APD说谎组)、20例无欺骗行为的患者(APD对照组)和20例正常人(正常对照组),应用磁共振进行任务状态下的功能像扫描。使用SPM2软件分析3组受试在不同条件下脑区激活的差异。结果在说谎任务中,APD说谎组对比APD对照组激活增加的脑区有:左楔前叶(BA19)、左颞叶(BA37、39)、左额叶(BA6、46)、左扣带回(BA24)、右枕叶及右小脑。APD对照组与正常对照组比较无激活显著增加的脑区。结论有说谎行为的APD人群,在说谎时有其特有的脑部激活模式,可能是其习惯性说谎行为的神经联系基础。
[Abstract]:Objective to explore the antisocial personality disorder (APD) patients with pathological lying. Methods Twenty patients with APD who had deceptive behavior were treated with APDD-activated mode of brain activation and the significance of revealing the mechanism of disease function. Methods Twenty APD patients with deceptive behavior were included in this study. 20 patients without deceptive behavior (APD control group) and 20 normal people (normal control group). Magnetic resonance imaging (MRI) was used to scan functional images in task state. SPM2 software was used to analyze the difference of brain activation in three groups under different conditions. The results were in the task of lying. In the APD lying group, the increased activation of BA19, BA37, BA6 and BA24 in the left anterior cuneiform lobe, left temporal lobe, left frontal lobe, and left cingulate gyrus in contrast to APD control group were observed. The right occipital lobe and right cerebellum. APD control group had no significant increase in brain activation as compared with the normal control group. Conclusion the APD group with lying behavior has its own brain activation pattern when lying. It may be the neural basis of its habitual lying behavior.
【作者单位】：红河哈尼族彝族自治州第一人民医院放射科;红河哈尼族彝族自治州第四人民医院内三科;
【分类号】：R445.2;R749.91
【正文快照】： 反社会人格障碍(antisocial personality disorder,APD)是常见的人格障碍之一,在不同国家的样本人口中,APD的终生患病率大概在2%~10%之间。患者普遍表现为不遵守社会规则、欺骗、冲动及好攻击等,给社会治安和经济带来危害,并且目前药物治疗效果不理想。已有的生物学及神经心理

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