放射性肠损伤后小肠干细胞再生的研究与进展

发布时间：2018-01-13 04:26

本文关键词：放射性肠损伤后小肠干细胞再生的研究与进展　出处：《中国组织工程研究》2017年29期 　论文类型：期刊论文

【摘要】：背景:放射性肠损伤造成小肠干细胞数量急剧减少和功能减退,导致损伤后的肠上皮修复非常困难,促进小肠干细胞数量和功能的恢复是当前治疗放射性肠损伤、修复受损肠上皮的研究热点。目的:综述放射性肠损伤后小肠干细胞补充来源及调控机制的最新研究进展。方法:分别以"小肠干细胞,放射性肠损伤;intestinal stem cell,radiation-induced intestinal injury"为检索词,由第一作者检索2010年1月至2016年6月相关期刊论文、Pub Med数据库及万方数据库相关文章,进行归纳总结。结果与结论:小肠干细胞的命运受多种信号通路的调控,研究比较明确的有Wnt/β-catenin、BMP、Notch和EGF信号通路。早期分泌型祖细胞在正常稳态下增殖缓慢,对放射性损伤不敏感,并且在一定条件下可重新逆转分化成为小肠干细胞,是"储备干细胞"的良好来源,而巢在早期分泌型祖细胞逆转分化为小肠干细胞的过程中发挥着重要作用。探究上述逆转分化过程的具体调控机制对于深入理解放射性肠损伤后肠上皮的修复过程,从而确立主动调控肠损伤修复的理念具有重要科学意义。
[Abstract]:Background: the number and function of small intestinal stem cells are reduced dramatically due to radioactive intestinal injury, and the repair of intestinal epithelium after injury is very difficult. Promoting the recovery of the number and function of small intestinal stem cells is the current treatment of radiation-induced intestinal injury. Objective: to review the recent progress in the supply and regulation of intestinal stem cells after radiation-induced intestinal injury. Methods: small intestinal stem cells and radiation-induced intestinal injury were used respectively. Intestinal stem cell radiation-induced intestinal injury "is the key word. From January 2010 to June 2016, the Chinese periodical full-text database Pub Med database and Wanfang database were searched by the first author. Results and conclusions: the fate of small intestinal stem cells is regulated by many signaling pathways, and Wnt / 尾 -cateninine BMP is clearly studied. Notch and EGF signaling pathway. The early secretory progenitor cells proliferate slowly under normal steady state, are insensitive to radiation damage, and can reverse differentiation into small intestinal stem cells under certain conditions. Is a good source of stem cells. Nests play an important role in the process of reversing the differentiation of secretory progenitor cells into small intestinal stem cells. Cheng. Therefore, it is of great scientific significance to establish the idea of active regulation of intestinal injury repair.
【作者单位】：南京大学医学院附属金陵医院/解放军南京军区南京总医院全军普通外科研究所;
【基金】：南京军区医药卫生科研基金(15DX018)~~
【分类号】：R730.55
【正文快照】： 文章快速阅读:文题释义:小肠干细胞:位于隐窝的基底部,通常情况下,小肠干细胞在原位通过自我复制、更新,维持一定的常备小肠干细胞数量。此外,大部分小肠干细胞随机产生过渡扩增细胞,过渡扩增细胞经历4-6次快速分裂后,跨越隐窝-绒毛界限向上迁移并逐渐分化为成熟的上皮细胞。

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