维持性血液透析患者幽门螺杆菌感染及其治疗的研究进展

发布时间：2018-01-14 09:12

本文关键词：维持性血液透析患者幽门螺杆菌感染及其治疗的研究进展　出处：《吉林大学学报(医学版)》2017年01期 　论文类型：期刊论文

【摘要】：血液透析是急慢性肾功能衰竭患者肾脏替代治疗方式之一,其并发症是影响患者生存率的重要原因。血液透析的常见并发症除心脑血管疾病、肾性贫血、细菌感染、慢性肾脏病矿物质和骨代谢异常等外,消化道并发症也十分常见,包括慢性胃炎、消化性溃疡、上消化道出血和功能性消化不良等,维持性血液透析的慢性肾功能衰竭患者胃十二指肠并发症的发生与幽门螺杆菌的慢性感染有密切关联。虽然部分患者在维持性血液透析治疗期间甚至可出现血清幽门螺杆菌抗体自发转阴现象,但对于伴有幽门螺杆菌感染的血液透析患者仍建议进行根除治疗,序贯治疗和混合方案较标准三联疗法可能是更好的选择,不仅可提高其根除率,还可明显降低不良反应,早期根除幽门螺杆菌治疗可明显降低血液透析患者消化性溃疡出血的发生率。本文作者分别从维持性血液透析患者幽门螺杆菌感染的诊断、感染状况、根除治疗的必要性和根除治疗方案的选择等方面进行了综述。
[Abstract]:Hemodialysis is one of the methods of renal replacement therapy in patients with acute and chronic renal failure. The complications of hemodialysis are the important factors affecting the survival rate of patients. The common complications of hemodialysis include cardiovascular and cerebrovascular diseases and renal anemia. Bacterial infection, chronic kidney disease, mineral and bone metabolism abnormalities, gastrointestinal complications are also very common, including chronic gastritis, peptic ulcer, upper gastrointestinal bleeding and functional dyspepsia. The occurrence of gastroduodenal complications in patients with chronic renal failure during maintenance hemodialysis is closely related to the chronic infection of Helicobacter pylori. Although some patients may even develop serum during maintenance hemodialysis treatment. Helicobacter pylori antibody turned negative spontaneously. However, for hemodialysis patients with Helicobacter pylori infection, eradication therapy is still recommended. Sequential therapy and mixed regimen may be a better choice than standard triple therapy, which can not only improve the eradication rate. It can also significantly reduce the adverse reactions. Early eradication of Helicobacter pylori can significantly reduce the incidence of peptic ulcer bleeding in hemodialysis patients. The necessity of eradication therapy and the choice of eradication therapy are reviewed.
【作者单位】：吉林大学第一医院;北京协和医院肾内科;陕西省延安市人民医院感染科;吉林大学中日联谊医院介入科;
【基金】：吉林省卫计委重点实验室项目资助课题(2011Z027)
【分类号】：R692.5;R57
【正文快照】： 屈昊1,2,何学学3,秦岩2,季尚玮4(1.吉林大学第一医院,吉林长春130021;2.北京协和医院肾内科,北京100730;3.陕西省延安市人民医院感染科,陕西延安716000;4.吉林大学中日联谊医院介入科,吉林长春130033)血液透析是急慢性肾功能衰竭患者肾脏替代治疗方式之一。目前,全球接受血液

【相似文献】