全球EV-A71的基因型分布

发布时间：2018-01-16 11:49

本文关键词：全球EV-A71的基因型分布　出处：《病毒学报》2017年03期 　论文类型：期刊论文

【摘要】：肠道病毒A组71型(EV-A71)是引起手足口病暴发流行的主要病原体,也是除脊髓灰质炎病毒以外最为重要的人肠道病毒病原体。截止2017年2月,全球报道的EV-A71共包括7个基因型(A~G)和14个基因亚型,其中B基因型和C基因型是目前全球流行的优势基因型,目前已鉴定B基因型有8个基因亚型(B0~B7),C基因型有6个基因亚型(C1~C6)。C4基因亚型中C4a进化分支是引起中国大陆近年手足口病大规模暴发流行的主要病原之一,也是引起手足口病重症和死亡的绝对优势病原体。本文对全球流行的EV-A71基因(亚)型的地理和年代分布、新基因型的发现进行了系统的归纳分析,为中国检测和监测引起HFMD流行的EV-A71基因型或亚型的动态变化提供基础数据。
[Abstract]:Enterovirus group A 71 (EV-A71) is the main pathogen causing HFMD outbreak. EV-A71 is also the most important pathogen of human enterovirus besides poliovirus. As of February 2017, the reported EV-A71 in the world included 7 genotypes and 14 gene subtypes. Among them, genotype B and genotype C are the dominant genotypes in the world. At present, 8 gene subtypes of genotype B have been identified. The evolutionary branch of C4a in the C genotype of C1C6, C6, C4 is one of the major pathogens causing the large-scale outbreak of HFMD in mainland China in recent years. It is also the dominant pathogen causing severe hand, foot and mouth disease and death. In this paper, the geographical and chronological distribution of the global epidemic EV-A71 gene (subtype) and the discovery of new genotypes were systematically summarized and analyzed. To provide basic data for detecting and monitoring the dynamic changes of EV-A71 genotypes or subtypes that cause HFMD epidemic in China.
【作者单位】：中国疾病预防控制中心病毒病预防控制所国家卫生计生委医学病毒与病毒病重点实验室世界卫生组织西太平洋区脊髓灰质炎参比实验室;
【基金】：国家重点研发课题(项目号:2016YFC1200905),题目:重要新发突发病原体应急处置方案与规范研究
【分类号】：R440
【正文快照】： 肠道病毒属于小RNA病毒科肠道病毒属,是引起包含脊髓灰质炎、无菌性脑膜炎、手足口病(Hand foot and mouth disease,HFMD)等疾病的重要病原。参考国际病毒学分类委员会数据,肠道病毒属已包含12个分类学组(肠道病毒EV-A~H,J,鼻病毒RV-A~C,2016年提出将骆驼来源的EV-I划分为新组

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