不孕症妇女衣原体和支原体感染及耐药性分析

发布时间：2018-01-20 00:59

本文关键词： 支原体衣原体不孕症药敏试验　出处：《中华医院感染学杂志》2017年17期 　论文类型：期刊论文

【摘要】：目的探讨支原体及衣原体感染在不孕症妇女中的检出率,并对支原体进行药敏分析,以期指导临床、提高治疗不孕症的临床疗效。方法选择2014年3月-2016年12月到医院就诊不孕症妇女140例为观察组,选择同期到医院进行体检的113例健康妇女作为对照组,分别对两组研究对象留取标本,检测两组研究对象支原体及衣原体的感染率,并对支原体进行药敏分析。结果观察组患者解脲脲支原体(Uu)、沙眼衣原体(Ct)、人型支原体(MH)+Uu以及Uu+Ct检出率均较对照组升高,差异有统计学意义(P0.05);观察组支原体与衣原体感染有相关性(r=0.687,P0.05);Uu对四环素类抗菌药物有较高的敏感性,其次为氟喹诺酮类抗菌药物,而对红霉素类抗菌药物敏感性较低,对环丙沙星敏感性最低;MH+Uu混合感染者对四环素类较敏感,其次是交沙霉素,而对红霉素及阿奇霉素的敏感性较低,对氟喹诺酮等类抗菌药物不敏感;Uu感染对12种抗菌药物全敏感有3株,无全耐药株,对4种抗菌药物耐药的比率最高,为23.61%;MH+Uu感染对12种抗菌药物耐药率较高,对不少于8种药物耐药,其中耐10种药物的比率最高,为28.57%。结论支原体及衣原体感染与女性不孕症的发生有直接联系,应结合药敏试验有针对性的进行治疗,并应将检测支原体、衣原体感染作为不孕症妇女的常规检查项目之一。
[Abstract]:Objective to investigate the detection rate of mycoplasma and chlamydia infection in infertile women and to analyze the drug sensitivity of mycoplasma in order to guide clinical practice. Methods from March 2014 to December 2016, 140 women with infertility were selected as observation group. 113 healthy women who went to hospital for physical examination at the same time were selected as control group. The specimens were collected from two groups of subjects and the infection rates of mycoplasma and chlamydia were detected. Results Ureaplasma Urealyticum Ureaplasma Urealyticum, Chlamydia trachomatis Chlamydia trachomatis, MHH) UU and UU Ct were higher in the observation group than in the control group. The difference was statistically significant (P 0.05). There was a correlation between mycoplasma and chlamydia infection in the observation group. UU had a higher sensitivity to tetracycline antibiotics, followed by fluoroquinolones, but less sensitive to erythromycin and ciprofloxacin. The mixed infection of MHUu was more sensitive to tetracycline, followed by josamycin, but less sensitive to erythromycin and azithromycin, and not sensitive to fluoroquinolones and other antimicrobial agents. Three strains of UU infection were completely sensitive to 12 kinds of antimicrobial agents, but no strains were totally resistant to antibiotics, and the rate of resistance to 4 kinds of antibiotics was the highest (23.61%). The resistance rate of MHUU infection to 12 kinds of antimicrobial agents was higher than that to no less than 8 kinds of drugs, and 10 of them had the highest resistance rate. Conclusion Mycoplasma and chlamydia infection is directly related to the occurrence of female infertility, should be combined with the drug sensitivity test targeted treatment, and should be detected mycoplasma. Chlamydia infection is one of the routine tests for infertile women.
【作者单位】：海口市第三人民医院妇产科;海口市人民医院妇产科;
【分类号】：R446.5;R711.6
【正文快照】： 不孕症是指夫妻间有正常的性生活,且未采取避孕措施,但未成功妊娠的妇女。现今仍未对不孕症在时间上的诊断标准进行统一,且国内外关于婚后受孕时间的标准极为悬殊,因此诊断不孕症的时限上多有变动。我国传统的不孕症诊断标准是同居3年未避孕而未受孕,但近年又有主张认为夫妇同

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