接触压力作用下皮肤形变对于漫反射光谱测量影响研究

发布时间：2018-01-21 12:57

  本文关键词： 近红外光谱 接触压力 光学参数 漫反射　出处：《光谱学与光谱分析》2017年10期 　论文类型：期刊论文

【摘要】：人体成分无创光谱检测过程中,测量条件特别是探头压力造成的组织形变在一定程度上影响光谱测量结果。利用物理模型与仿真方法,定量分析了探头接触压力作用下皮肤组织应变,及光学参数与漫反射光谱变化。首先,在多层皮肤组织物理复合模型基础上,结合生物组织固液两相组成特性,定量分析了压力作用下各层皮肤组织形变大小以及成分变化。该模型将皮肤力学模型简化为固态弹性结构及包含于其中的牛顿流体,利用有限元方法,分别模拟不同压力作用下多层皮肤组织应变大小及时间特性,并根据各层组织体积及水含量变化,定量计算其散射系数及吸收系数改变。然后,利用Monte Carlo方法模拟压力作用前后光在组织中传输过程,定量分析了探头压力对漫反射光谱中所包含人体成分检测有效信息的影响。实验结果表明,在光纤探头接触压力作用下,人体皮肤组织中真皮层厚度变小,自由水体积减小,引起散射特性及光子传输路径改变,使得漫反射光谱中所包含的有效光谱信息下降。该研究结果为优化人体漫反射光谱测量策略,提高测量准确性以及重复性提供了参考。
[Abstract]:In the process of noninvasive spectral measurement of human components, the measurement conditions, especially the tissue deformation caused by probe pressure, affect the results of spectral measurement to some extent. The physical model and simulation method are used. Quantitative analysis of skin tissue strain, optical parameters and diffuse reflectance spectrum changes under the contact pressure of probe. Firstly, based on the multi-layer skin tissue physical composite model, combined with biological tissue solid-liquid two-phase composition characteristics. Quantitative analysis of skin tissue deformation and composition changes under pressure. The skin mechanics model is simplified as solid elastic structure and Newtonian fluid contained in it, and finite element method is used. The strain and time characteristics of multi-layer skin under different pressures were simulated, and the scattering coefficient and absorption coefficient were calculated quantitatively according to the changes of tissue volume and water content in each layer. Monte Carlo method was used to simulate the propagation of light in tissues before and after pressure. The effect of probe pressure on the effective information of human body component detection contained in diffuse reflectance spectrum was quantitatively analyzed. The experimental results showed that the thickness of dermis in human skin tissue decreased under the contact pressure of optical fiber probe. The decrease of free water volume leads to the change of scattering characteristics and photon transmission path, which results in the decrease of the effective spectral information contained in diffuse reflectance spectroscopy. The results of this study are to optimize the measurement strategy of human diffuse reflectance spectrum. The accuracy and repeatability of measurement are improved.
【作者单位】： 天津大学精密测试技术及仪器国家重点实验室;天津大学精密仪器与光电子工程学院;
【基金】：国家自然科学基金项目(81401454,81471698,81671727) 中国博士后科学基金项目(2013M541174) 中国博士后国际交流计划(20140066) 天津市应用基础与前沿技术研究计划(16JCZDJC31200) 国家(863)高技术研究发展计划(012AA022602)资助
【分类号】：O657.33;R443
【正文快照】： 引　言　　人体成分无创检测研究中,漫反射光谱方法具有无创伤、测量方便、可应用于多成分体系等优点,在生物光学研究以及临床医学中得到广泛应用[1-3]。实际应用中,漫反射光谱检测系统常采用光纤与待测组织直接接触的测量方式,光纤探头以一定压力作用于皮肤组织,来消除运动伪，

本文编号：1451540