高通量透析对同型半胱氨酸水平及主要心血管事件的影响

发布时间：2018-01-24 17:23

本文关键词： 尿毒症同型半胱氨酸高通量血液透析心血管疾病　出处：《实用医学杂志》2017年10期 　论文类型：期刊论文

【摘要】：目的:观察高通量血液透析(high-flux hemodialysis,HFD)对维持性血液透析(maintenancehemodialysis,MHD)患者同型半胱氨酸(homocysteine,Hcy)水平及主要心血管事件的影响。方法:选取符合入选条件的患者,随机分为高通量血液透析(HFD)组及低通量血液透析(HD)组,观察12月,主要观察血清同型半胱氨酸(Hcy)、记录主要心血管事件及各临床指标的变化情况并进行相关分析。结果:两组各入选30例,患者年龄、性别、原发病、透析龄等相匹配,HFD组与HD组透前Hcy基线值水平比较(21.02±11.79 vs.19.86±6.97 mmol/L)差异无统计学意义(P=0.162),观察12月后HFD与HD组透前血Hcy水平差异有统计学意义(20.29±11.45 mmol/L vs.24.57±13.23 mmol/L),(P=0.045);观察期间HFD组主要心血管事件发生率较HD组(10.0%vs.33.3%)显著降低(P=0.034),HFD组无死亡,HD死亡1例,全因死亡率差异无统计学意义(P0.05)。结论:长期HFD治疗显著降低MHD患者透前Hcy水平及主要心血管事件的发生率。
[Abstract]:Objective: to observe high-flux hemodialysis in high-flux hemodialysis. HFDs were used to treat homocysteine homocysteine in patients with maintenance hemodialysis (HD). Methods: patients who met the criteria were randomly divided into two groups: high flux hemodialysis group and low flux hemodialysis group. The changes of main cardiovascular events and clinical indexes were recorded and analyzed. Results: 30 patients were enrolled in the two groups with age, sex and primary disease. Dialysis age matched. There was no significant difference in baseline Hcy level between HFD group and HD group (21.02 卤11.79 vs.19.86 卤6.97 mmol / L). P0. 162). After December, there was a significant difference in Hcy level between HFD and HD group (P < 0.05). 20.29 卤11.45 mmol/L vs.24.57 卤13.23 mmol / L). P0. 045; During the observation period, the incidence of major cardiovascular events in the HFD group was significantly lower than that in the HD group (10.0vs.33.3). Conclusion: Long-term HFD treatment can significantly reduce the level of Hcy and the incidence of major cardiovascular events in patients with MHD.
【作者单位】：广东省佛山市第一人民医院(中山大学附属佛山医院)肾内科;
【基金】：佛山市卫生和计生局医学科研课题(编号:2015127) 2013年佛山市创新型城市建设科技项目-佛山市科技创新平台(编号:2013AG10008)
【分类号】：R54;R692.5
【正文快照】： 维持性血透患者的全因死亡率居高不下,而心血管疾病(cardiovascular disease,CVD)是尿毒症患者最常见的并发症及死亡原因。心血管疾病常见的危险因素为高血压、高血脂、糖尿病、吸烟等, 然而近期有研究证明高同型半胱氨酸血症(Hcy)不但是普通人群CVD的高危因素,而且是维持性

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