青海地区五个民族孕妇不规则抗体筛查探析

发布时间：2018-01-29 03:52

  本文关键词： 民族 不规则抗体 孕妇　出处：《青海大学》2017年硕士论文　论文类型：学位论文

【摘要】：目的通过检测青海地区汉族、藏族、回族、土族及撒拉族五个民族孕妇的不规则抗体,以期发掘在临床上具有意义的不规则抗体,初步摸索不规则抗体在五个民族的分布特征。方法对20l4年1月至2017年1月在青海红十字医院就诊的汉族、藏族、回族、土族、撒拉族五个民族孕妇共11991例进行不规则抗体的筛选及鉴定,获取不规则抗体阳性率及其具体类型在青海地区五个民族孕妇中的分布特征。结果(1)青海地区五个民族孕妇不规则抗体阳性检出率分别为:撒拉族孕妇为(1.89%)、回族孕妇为(1.05%)、土族孕妇为(0.50%)、藏族孕妇为(0.39%)、汉族孕妇为(0.35%);五个民族孕妇之间的不规则抗体阳性率比较:汉族、藏族孕妇分别与回族、撒拉族孕妇的不规则抗体阳性率比较,均P0.05差异有统计学意义,而其他民族之间孕妇不规则抗体阳性率比较,均P0.05差异无统计学意义;(2)五个民族孕妇中不规则抗体具体类型的出现频率及分布存在差异性;(3)五个民族孕妇检出63例不规则抗体,其中RH血型系统共54例最多见,不规则抗体以抗-D(19例)最多见,抗-E(14例)是其次,抗-c E(9例)、抗-c(7例)、抗-M(4例)也较多见,另外可见抗-e、抗-CD、抗-Lea、抗-P1、冷抗体;不规则抗体主要以Ig G类型抗体为主;(4)汉族、藏族、回族≥2次妊娠史孕妇的不规则抗体检出率高于首次妊娠孕妇,均P0.05差异有统计学意义,而土族、撒拉族≥2次妊娠史孕妇的不规则抗体检出率与首次妊娠孕妇相比较,均P0.05差异无统计学意义。结论(1)青海地区汉族、藏族、回族、土族及撒拉族五个民族孕妇不规则抗体及其具体类型的分布可能存在民族特异性;(2)临床上除了常规进行ABO血型鉴定、Rh D检测,需添加Rh E、Rhc E、Rhc等其他临床常见不规则抗体检测,才能更好地避免HTR及HDN的发生。
[Abstract]:Objective to detect irregular antibodies of pregnant women of Han, Tibetan, Hui, Tu and Sala nationalities in Qinghai area, and to explore the clinical significance of irregular antibodies. Methods from January to January 2017 in Qinghai Red Cross Hospital, Han, Tibetan, Hui and Tu nationality were studied. A total of 11991 pregnant women from five nationalities of Salar nationality were screened and identified for irregular antibodies. The positive rate of irregular antibody and its specific types were obtained among the pregnant women of five nationalities in Qinghai area. Results the positive rate of irregular antibody in the pregnant women of five nationalities in Qinghai area was as follows: the positive rate of irregular antibody in the pregnant women of Salar nationality was (. 1.89). The number of pregnant women of the Hui nationality was 1.05%, that of the pregnant women of the Tu nationality was 0.50%, that of the pregnant women of the Tibetan nationality was 0.39%, and that of the pregnant women of the Han nationality was 0.35%. Comparison of irregular antibody positive rate among pregnant women of five nationalities: Han, Tibetan pregnant women and Hui, Sala pregnant women were compared with irregular antibody positive rate, all the differences were statistically significant (P0.05). However, there was no significant difference in the positive rate of irregular antibody among other ethnic groups (P0.05). (2) the frequency and distribution of irregular antibody in pregnant women of five nationalities were different. (3) 63 cases of irregular antibodies were detected in pregnant women of five nationalities, of which 54 cases were found in RH blood group system, 19 cases were irregular antibodies, and 14 cases were anti-EG). There were also 9 cases of anti -c Em, 7 cases of anti-cor, 4 cases of anti-MU). In addition, anti-E, anti-CD, anti-Lea, anti-P 1, cold antibody were also found. The irregular antibody was mainly IgG type antibody. 4) the detection rate of irregular antibody in pregnant women of Han, Tibetan and Hui nationalities 鈮，

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