基于表面重建螺旋型铂铱电极的葡萄糖生物传感器

发布时间：2018-02-01 08:33

本文关键词： 葡萄糖传感器螺旋型铂铱电极化学腐蚀电化学沉积检测范围　出处：《高等学校化学学报》2017年07期 　论文类型：期刊论文

【摘要】：通过对螺旋型铂铱电极表面进行化学腐蚀和电化学沉积铂纳米粒子实现电极表面的重建和优化,研究了螺旋型铂铱电极在不同腐蚀时间和电沉积时间下的形貌及对过氧化氢(H2O2)的催化活性.对表面重建的工作电极涂覆氧化酶和半透膜,制备出了铂纳米粒子/葡萄糖氧化酶/环氧聚氨酯酶电极,并将其用作葡萄糖传感器的工作电极.传感器计时电流检测结果表明,表面重建后的酶电极传感器对葡萄糖的检测范围扩大为2~45 mmol/L,优于裸铂铱酶电极传感器,电流响应值和灵敏度得到明显提升,同时传感器还具有良好的稳定性和选择性.
[Abstract]:The surface of the spiral platinum-iridium electrode was reconstructed and optimized by chemical corrosion and electrochemical deposition of platinum nanoparticles. The morphology of the helical platinum-iridium electrode at different corrosion time and electrodeposition time and its catalytic activity to H _ 2O _ 2 hydrogen peroxide were studied. The surface reconstructed working electrode was coated with oxidase and semi-permeable film. Platinum nanoparticles / glucose oxidase / epoxy polyurethane enzyme electrode was prepared and used as the working electrode of glucose sensor. After surface reconstruction, the detection range of glucose by enzyme electrode sensor was expanded to 2 ~ 45 mmol / L, which was better than that of naked platinum iridium electrode sensor, and the current response and sensitivity were improved obviously. At the same time, the sensor also has good stability and selectivity.
【作者单位】：上海第二工业大学工学部环境与材料工程学院;
【基金】：国家自然科学基金(批准号:61471233,21504051) 上海高校特聘教授(东方学者)计划项目上海市教委曙光计划项目(批准号:14SG52)资助~~
【分类号】：O657.1;R446.1
【正文快照】： 糖尿病是一种引起人体血糖水平异常升高的临床慢性疾病[1],会诱发高血压、心血管疾病、肾衰竭、手足坏死、神经紊乱等多种病症,对人的生命健康有极大危害[2,3].据世界卫生组织统计,全世界范围内每年有400万人直接或间接由糖尿病导致死亡,所以对糖尿病患者的血糖值应该进行严格

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