用于检测生物体系中线粒体活性氧的荧光探针（英文）

发布时间：2018-02-03 11:23

本文关键词： 荧光探针线粒体活性氧小分子活细胞　出处：《物理化学学报》2017年08期 　论文类型：期刊论文

【摘要】：线粒体不仅是细胞的能量单元,还是重要的活性氧产生场所。线粒体内的活性氧与正常的生理功能和人类疾病具有紧密的联系,包括细胞信号传导,损伤核酸蛋白质以及诱导氧化应激。然而,线粒体活性氧和细胞病态之间的复杂联系还研究得不够透彻。有效检测线粒体内活性氧的手段有助于研究线粒体内活性氧在各种人类疾病中所起的作用。近年来,发展了许多具有高灵敏度和选择性的荧光探针用于检测线粒体内活性氧。基于这一点,我们综述了用于选择性检测线粒体内活性氧的小分子荧光探针的研究进展,并详细讨论了荧光探针的设计、合成、特点及其应用。
[Abstract]:Mitochondria are not only the energy unit of cells, but also important sites for the production of Ros. Ros in mitochondria are closely related to normal physiological functions and human diseases, including cell signal transduction. Damage nucleic acid proteins and induce oxidative stress. The complex relationship between mitochondrial reactive oxygen species and cellular morbidities has not been thoroughly studied. Effective detection of reactive oxygen species in mitochondria is helpful to study the role of mitochondrial reactive oxygen species in various human diseases in recent years. . A number of highly sensitive and selective fluorescent probes have been developed for the detection of reactive oxygen species in mitochondria. The research progress of small molecular fluorescent probes for selective detection of reactive oxygen species in mitochondria is reviewed. The design, synthesis, characteristics and applications of fluorescent probes are discussed in detail.
【作者单位】：中国科学院大连化学物理研究所分子反应动力学国家重点实验室;
【基金】：supported by the National Natural Science Foundation of China(21503224,21673237)~~
【分类号】：O657.3;R446
【正文快照】： 1 IntroductionReactive oxygen species(ROS)is a generic term of a seriesof reactive species,including superoxide anion(O2·-),hydrogen peroxide(H12O2),singlet oxygen(O2),hydroxylradical(OH·),peroxyl radical(ROO·),hypochlorous acid/hypochlorite(HOCl/-OCl

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