重庆地区4414例泌尿生殖道支原体检测及药敏分析

发布时间：2018-02-04 12:07

本文关键词： 支原体感染解脲支原体泌尿道感染尿道炎药敏试验　出处：《重庆医学》2017年05期 　论文类型：期刊论文

【摘要】：目的研究解脲支原体(Uu)和人型支原体(Mh)在非淋球菌性尿道炎(NGU)疑似感染者中的感染率和药敏情况。方法使用安图生物支原体培养鉴定计数药敏试剂盒检测4 414份疑似泌尿生殖道感染者临床标本。结果 4 414份标本中,检出支原体阳性感染者2 295例,阳性率51.99%,其中Uu和Mh的单一感染阳性率分别为40.69%和2.08%,两者共同感染阳性率9.22%。交沙霉素(JOS)、多西环素(DOX)、克拉霉素(CLA)、加替沙星(GAT)和红霉素(ERY)敏感率分别为96.03%、95.51%、78.69%、77.21%和72.55%。罗红霉素(RXT)、甲砜霉素(THI)、克林霉素(CLI)和克拉霉素(CLA)的耐药率分别为16.91%、22.27%、41.96%和17.60%。结论 Uu是NGU感染中的主要病原体,临床推荐使用DOX、JOS、GAT和ERY作为一线药物,而不适宜使用耐药率高的RXT、THI、CLI和CLA。
[Abstract]:Objective to study the application of Ureaplasma Urealyticum (UU) and Mycoplasma hominis (Mh) in nongonococcal urethritis (nongonococcal urethritis). Methods 4 414 clinical specimens of suspected genitourinary tract infections were detected by Antu biological mycoplasma culture assay kit. 4. 414 specimens were collected. 2 295 cases of mycoplasma positive infection were detected, the positive rate was 51. 99%. The positive rates of single infection of UU and Mh were 40.69% and 2.08% respectively. The positive rate of co-infection was 9.22.The positive rate of josamycin, doxycycline, clarithromycin was 9.22. josamycin, doxycycline, clarithromycin (Cla). The sensitivity rates of gatifloxacin (GATT) and erythromycin (ERY) were 96.03and 95.51, 77.21% and 72.55%, respectively. The resistance rates of thiamphenicol, clindamycin (CLI) and clarithromycin (Cla) were 16.91% and 22.27%, respectively. Conclusion UU is the main pathogen of NGU infection. It is recommended that NGU and ERY be used as first-line drugs in clinic. However, it is not suitable to use RXT THICLI and CLAs with high drug resistance rate.
【作者单位】：重庆市中医院检验科;重庆市铜梁区人民医院核医学科;
【基金】：基金项目:重庆市科委基础科学与前沿技术研究(cstc2015jcyjA10005)
【分类号】：R446.5;R691.3
【正文快照】： 支原体是一类缺乏细胞壁,呈高度多形性,能通过除菌滤器的最小原核微生物,定植于尿道、生殖道黏膜上皮细胞,感染人体后会引发不孕不育、早产、流产、新生儿感染等严重后果。它是非淋菌性尿道炎(NGU)的主要致病菌之一,临床上耐药菌株呈现增多趋势[1]。支原体的临床治疗上抗菌药

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