早期骨量减少的核医学诊疗实验研究

发布时间：2018-02-07 09:09

本文关键词： mTc-MDP骨显像早期骨量减少骨质疏松核医学　出处：《中国骨质疏松杂志》2017年03期 　论文类型：期刊论文

【摘要】：目的应用核素~(99)mTc-MDP骨骼显像评判早期骨量减少并早期干预治疗的实验研究。方法应用肌肉注射地塞米松磷酸钠针剂(DX)制作兔早期骨量减少模型和骨质疏松模型并采用~(99)Tc-MDP治疗,每周一次,共14w。经核素骨骼显像的感兴趣区部位与体外固定放射性标准源(RSF)的比值以及骨病理学、骨形态计量学、骨密度、骨生物力学、血清骨碱性磷酸酶(BALP)、骨钙素(BGP)、腰椎X、CT摄片等指标比较在各组间存在的差异,并对疗效作出评判。结果经注射不同剂量DX后对实验兔的早期骨量减少模型组和骨质疏松模型组进行骨组织病理切片,骨形态计量学、骨密度、骨生物力学、BALP、BGP等检测指标,证实动物模型成立。治疗14 w后,早期骨量减少治疗组在模型的基础上骨病理学显示:股骨头的骨小梁排列基本规则,骨小梁有所增粗;而骨质疏松治疗组骨病理则表现为骨小梁略有稀疏,骨小梁粗细不均匀,但无断裂现象。早期骨量减少模型、骨质疏松模型骨组织对核素99mTc-MDP骨骼显像剂摄取明显高于正常对照组(P0.05),而治疗组较对应模型组有所下降(P0.05)。早期骨量减少治疗组与正常组比较骨密度、骨形态计量指标变化不大(P0.05),但是骨显像剂摄取明显高于正常组(P0.05)。骨质疏松治疗组与正常组比较,骨密度、骨生物力学、BALP、BGP均有较明显的改善,以骨质疏松治疗组更明显(P0.05)。结论核素~(99)mTc-MDP骨骼显像能够发现不同个体的早期骨质疏松现象,同时在早期骨量减少进行干预治疗的疗效将明显优于严重骨质疏松期。
[Abstract]:Objective to evaluate early bone mass reduction and early intervention therapy by radionuclide 99m Tc-MDP bone imaging. Methods the rabbit early bone mass reduction model and osteoporosis model were made by intramuscular injection of dexamethasone sodium phosphate injection. Once a week for 14 ws.The ratio of region of interest to external fixation of RSFs in radionuclide bone imaging and bone pathology, bone morphometry, bone mineral density, bone biomechanics, There were significant differences in serum alkaline phosphatase (BALP), osteocalcin (BGP) and lumbar X-ray tomography (XCT). Results the early osteopenia model group and the osteoporosis model group were injected with different doses of DX. The pathological sections of bone tissue, bone morphometry, bone mineral density, bone biomechanics and BALP BGP were measured. It was confirmed that the animal model was established. After 14 weeks of treatment, the bone mass reduction in the early treatment group on the basis of the model bone pathology showed: the bone trabecular arrangement of the femoral head basic rules, trabecular bone thickening; In the osteoporosis treatment group, the bone pathology showed that the trabecular bone was slightly sparse, the trabecular thickness was not uniform, but there was no fracture. The bone tissue uptake of bone radionuclide 99mTc-MDP in osteoporosis model was significantly higher than that in the normal control group (P 0.05), while in the treatment group it was lower than that in the corresponding model group (P 0.05). The bone mineral density of the treatment group was lower than that of the normal group, and the bone mineral density of the treatment group was lower than that of the normal group. The bone morphology was not changed significantly, but the uptake of bone scintigraphy was significantly higher than that of the normal group. The bone mineral density and bone biomechanical BALPGP of the osteoporosis treatment group were significantly improved compared with the normal group. Conclusion the bone imaging of radionuclide 99mTc-MDP can detect early osteoporosis in different individuals, and the effect of interventional therapy in the reduction of bone mass in early stage will be better than that in severe osteoporosis.
【作者单位】：上海市黄浦区中心医院核医学科;
【分类号】：R580;R817.1

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