DTI及~1H-MRS对肝豆状核变性脑组织微观结构损害的定量研究

发布时间：2018-02-07 11:19

本文关键词： 肝豆状核变性磁共振波谱学扩散张量成像　出处：《临床放射学杂志》2017年06期 　论文类型：期刊论文

【摘要】：目的应用扩散张量成像(DTI)和氢质子磁共振波谱成像(~1H-MRS)评估肝豆状核变性(HLD)患者脑灰质核团及白质的微观结构损害。方法选取HLD患者26例及正常对照组20名行DTI及~1H-MRS成像,比较两组不同脑区部分各向异性值(FA)、平均扩散系数(ADC)、扩散张量本征(E1、E2、E3)值及NAA/Cr、Cho/Cr、NAA/Cho比值的差异。结果 HLD患者双侧壳核及丘脑的FA及ADC值高于正常组,其中壳核差异有统计学意义(P0.05),而双侧丘脑差异无统计学意义(P0.05);双侧额叶白质及胼胝体压部FA值降低,ADC值升高,与正常组对比差异均有统计学意义(P0.05);HLD组各兴趣区本征值均高于对照组,其中双侧壳核E1、E2、E3值、双侧丘脑E1值、双侧额叶白质及胼胝体压部E2、E3值差异均有统计学意义(P0.05);HLD组双侧壳核、双侧丘脑及胼胝体压部的NAA/Cr比值低于正常对照组,差异有统计学意义(P0.05)。结论 DTI结合~1H-MRS技术可以提供HLD患者脑实质的代谢及扩散量化指标,更真实地反映脑实质损害的程度。
[Abstract]:Objective to evaluate the microstructure of gray matter and white matter in patients with hepatolenticular degeneration (HLDD) by using diffusion imaging (DTI) and proton magnetic resonance spectroscopy (1H-MRS). Methods 26 patients with HLD and 20 normal controls were selected for DTI and 1H-MRS imaging. The values of partial anisotropy in different brain regions were compared between the two groups. The average diffusion coefficient was higher than that in the normal group. Results the FA and ADC values of bilateral putamen nucleus and thalamus in patients with HLD were higher than those in the normal group. There was significant difference in putamen nucleus (P 0.05), but no significant difference in bilateral thalamus (P 0.05), and the FA value of bilateral frontal white matter and corpus callosum decreased. Compared with the normal group, the difference was statistically significant (P 0.05). The intrinsic values of each region of interest in the HLD group were higher than those in the control group. There were significant differences in the bilateral putamen nucleus E _ (1) E _ (2) E _ (2) E _ (3), the bilateral thalamus E _ (1) value, the bilateral frontal white matter and the splenium callosum E _ (2 +) E _ (3) in the bilateral putamen nucleus of the bilateral putamen nucleus in the P0.05HLD group. The ratio of NAA/Cr in bilateral thalamus and corpus callosum was lower than that in normal control group (P 0.05). Conclusion DTI combined with 1H-MRS technique can provide quantitative index of cerebral parenchyma metabolism and diffusion in patients with HLD, and more truly reflect the degree of cerebral parenchyma damage.
【作者单位】：安徽医科大学第二附属医院放射科;安徽省皖南康复医院放射科(芜湖市第五人民医院);
【分类号】：R445.2;R742.4

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