脓毒症患者休克指数与炎症反应、氧化应激反应、靶器官损伤的相关性研究

发布时间：2018-02-09 07:03

本文关键词： 脓毒症休克指数炎症反应氧化应激靶器官损伤　出处：《海南医学院学报》2017年04期 　论文类型：期刊论文

【摘要】：目的:探讨脓毒症患者休克指数与炎症反应、氧化应激反应、靶器官损伤的相关性。方法:收集2013年3月~2016年5月间本院收治的脓毒症患者70例,根据休克指数(SI)分为无休克组(SI0.5)11例、一般休克组(0.5≤SI≤2)42例、严重休克组(SI2.0)17例。入院后即刻,检测血清炎症因子、氧化应激指标、肝功能指标的含量。结果:严重休克组、一般休克组患者的血清白介素-1β(IL-1β)、白介素-8(IL-8)、肿瘤坏死因子α(TNF-α)、晚期蛋白氧化产物(AOPPs)、总胆红素(TB)、γ-转肽酶(GGT)、丙氨酸转氨酶(ALT)含量高于无休克组患者,抗炎因子白介素-10(IL-10)、白介素-13(IL-13)、可溶性肿瘤坏死因子Ⅰ型受体(sTNF-RI)、过氧化氢酶(CAT)、谷胱甘肽过氧化物酶(GSH-Px)、超氧化物歧化酶(SOD)含量低于无休克组患者;严重休克组患者的血清IL-1β、IL-8、TNF-α、AOPPs、TB、GGT、ALT含量高于一般休克组患者,IL-10、IL-13、sTNF-RI、CAT、GSH-Px、SOD含量低于一般休克组患者。结论:脓毒症患者休克指数越高,炎症反应、氧化应激反应、靶器官损伤越严重,两者呈正相关关系。
[Abstract]:Objective: to investigate the correlation between shock index and inflammatory reaction, oxidative stress response and target organ injury in sepsis patients. Methods: from March 2013 to May 2016, 70 patients with sepsis were treated in our hospital. According to shock index (SI), 11 patients were divided into no shock group (n = 11), normal shock group (n = 42), severe shock group (n = 42), and severe shock group (n = 17). Immediately after admission, serum inflammatory factor, oxidative stress index and liver function index were measured. The serum levels of IL-1 尾, IL-8, TNF- 伪, AOPPsO, TBX, GGTG, ALT in patients with shock were significantly higher than those in patients without shock. The contents of anti-inflammatory factor IL-10, IL-13, soluble tumor necrosis factor I receptor sTNF-RII, catalase CATX, glutathione peroxidase (GSH-PxN) and superoxide dismutase (SOD) were significantly lower than those in patients without shock. The level of serum IL-1 尾 -IL-8, TNF- 伪, TOPPsTBG-GTT in severe shock group was higher than that in normal shock group. Conclusion: the higher the shock index, the more inflammatory reaction, oxidative stress reaction, the more serious the target organ damage is in septic patients. There was a positive correlation between the two.
【作者单位】：广东省深圳市宝安区中心医院心血管内科;广东省深圳市宝安区中心医院急诊内科;广东省深圳市宝安区中心医院重症医学科;
【分类号】：R59

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