合并心血管疾病的透析患者的死亡危险因素分析

发布时间：2018-02-25 22:19

本文关键词： 心血管疾病透析危险因素病死率脑卒中　出处：《广东医学》2017年02期 　论文类型：期刊论文

【摘要】：目的探索合并心血管疾病(CVD)的透析患者的病死率及死亡危险因素。方法选取广州军区广州总医院及广州市第一人民医院共591例透析患者,采集基线人口统计学资料、合并症及实验室指标等,通过Cox回归模型探讨合并CVD的透析患者的病死率及死亡危险因素。结果共纳入终末期肾病患者591例,其中合并CVD的透析患者123例(CVD组),无CVD的透析患者468例(无CVD组)。CVD组患者平均年龄(59.37±15.94)岁。在总人群中,CVD组患者病死率要高于无CVD组患者(HR=2.893,95%CI:1.804~4.693,P0.001)。多因素分析发现,脑卒中(HR=3.802,95%CI:1.752~8.252,P=0.001)为CVD组的独立死亡危险因素,糖尿病(HR=2.974,95%CI:1.569~5.668,P=0.001)及高敏C反应蛋白(HR=1.107,95%CI:1.005~1.030,P=0.005)为无CVD组的独立死亡危险因素。结论合并CVD的透析患者病死率高于无CVD的透析患者,且脑卒中是合并CVD的透析患者的死亡独立危险因素。
[Abstract]:Objective to explore the patients with cardiovascular disease (CVD) mortality of patients on dialysis rate and risk factors of death. Methods a total of 591 cases in Genenral Hospital of PLA Guangzhou Military Area and Guangzhou No.1 People's Hospital dialysis patients, collected baseline demographics, comorbidities and laboratory indicators such as mortality, through the Cox regression model to explore the combined CVD patients on dialysis rate and risk factors of death were included in the results. In patients with end-stage renal disease in 591 cases, including 123 cases with CVD dialysis patients (CVD group), 468 patients with non dialysis CVD patients (CVD group) the average age of patients in group.CVD (59.37 + 15.94) years old. In the general population, the mortality rate of patients in group CVD was higher than that of non CVD patients (HR=2.893,95%CI:1.804~4.693, P0.001). Multivariate analysis showed that stroke (HR=3.802,95%CI:1.752~8.252, P=0.001) CVD group is the independent risk factors of death in diabetes (HR=, 2.974,95%CI:1.569~5.668, P=0.001) and high C, HR=1.107,95%CI:1.005~1.030 (P=0.005) is an independent risk factor of death in group CVD. Conclusion the mortality of patients with CVD combined with dialysis is higher than that of patients without CVD, and stroke is an independent risk factor for death of patients with CVD combined with dialysis.

【作者单位】：南方医科大学研究生学院;广州军区广州总医院肾内科;广州市第一人民医院肾内科;
【基金】：国家自然科学基金资助项目(编号:81270895,81360137) 广东省科技计划项目(编号:2014A030310060)
【分类号】：R54;R692.5

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