2015年齐齐哈尔市第一医院细菌耐药性监测

发布时间：2018-02-26 03:27

本文关键词： 抗菌药物细菌耐药性监测药物敏感性　出处：《中国感染与化疗杂志》2017年04期 　论文类型：期刊论文

【摘要】：目的了解齐齐哈尔市第一医院临床分离菌的分布及耐药性,为临床合理使用抗菌药物提供依据。方法采用自动化仪器对2015年1月1日-12月31日该院临床分离菌进行药敏试验,采用CLSI 2014年版标准判断药敏结果及WHONET 5.6软件进行数据分析。结果 2015年1月1日-12月31日收集临床分离菌5 162株,其中革兰阳性菌1 450株,占28.1%,革兰阴性菌3 712株,占71.9%。葡萄球菌属中甲氧西林耐药金黄色葡萄球菌和凝固酶阴性葡萄球菌的检出率分别为36.5%(255/698)和81.4%(180/221),未发现对万古霉素和利奈唑胺耐药的金黄色葡萄球菌。肠球菌属对万古霉素和利奈唑胺耐药率较低,其中检出1株对万古霉素耐药的屎肠球菌。大肠埃希菌、克雷伯菌属细菌和奇异变形杆菌产超广谱β内酰胺酶(ESBL)株平均检出率分别为39.9%(298/747)、26.1%(294/1 127)和15.6%(12/77),肠杆菌科细菌对碳青霉烯类、含β内酰胺酶抑制剂的复合制剂、阿米卡星耐药率相对较低。泛耐药鲍曼不动杆菌与泛耐药铜绿假单胞菌的检出率分别为36.6%(163/445)和1.8%(13/715)。结论细菌耐药性仍对临床构成严重威胁,应引起高度重视,临床微生物室应继续加强细菌耐药性监测,为临床提供更好的数据支持。
[Abstract]:Objective to investigate the distribution and drug resistance of clinical isolates in Qiqihar first Hospital, and to provide evidence for rational use of antimicrobial agents. Results from January 1st 2015 to December 31st, 5 162 clinical isolates were collected, including 1 450 Gram positive bacteria (28. 1%) and 3 712 Gram negative bacteria (3 712). The positive rates of methicillin-resistant Staphylococcus aureus and coagulase-negative staphylococcus were 36.5 / 698 and 81.4 / 180 / 221, respectively. No vancomycin and linazolamide resistant Staphylococcus aureus were found. Vancomycin and linazolamine resistance rates were low, Among them, one Enterococcus faecium resistant to vancomycin, Escherichia coli, Klebsiella and Proteus mirabilis producing extended-spectrum 尾 -lactamase (ESBL) strain were found to have an average detectable rate of 39.9% 747% 26.1% and 15.612% 77%, respectively. The resistance rate of amikacin was relatively low in the compound preparation containing 尾 lactamases inhibitor. The detectable rates of pan-resistant Acinetobacter baumannii and Pan-resistant Pseudomonas aeruginosa were 36.66% 163 / 445) and 1.88% 13 / 7150.Conclusion bacterial resistance is still a serious threat to clinical practice. The clinical microorganism room should continue to strengthen the monitoring of bacterial resistance to provide better data support for clinical.
【作者单位】：齐齐哈尔市第一医院检验科;
【分类号】：R446.5

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