抑郁症认知易感者脑灰质密度的基于体素的形态测量学分析

发布时间：2018-02-27 05:26

本文关键词： 抑郁症认知易感性基于体素的形态测量灰质密度磁共振成像　出处：《中南大学学报(医学版)》2017年06期 　论文类型：期刊论文

【摘要】：目的:探讨抑郁症认知易感者脑灰质密度的特征。方法:运用磁共振成像(MRI)技术采集30例抑郁症认知易感者及30例正常对照者的全脑解剖成像数据,应用基于体素的形态测量(voxel-based morphometry,VBM)方法分析比较两组研究对象全脑灰质密度的差异。结果:抑郁症认知易感者双侧脑岛、左侧小脑、右侧辅助运动区及左侧中央前回的灰质密度显著低于正常组(P0.001),而右侧额下回、右侧额中回及左侧楔叶的灰质密度显著高于正常组(P0.001)。结论:抑郁症认知易感者存在脑灰质密度的异常,这可能是抑郁认知易感性的神经生物学机制之一。
[Abstract]:Objective: to investigate the characteristics of gray matter density in patients with cognitive susceptibility to depression. Methods: magnetic resonance imaging (MRI) technique was used to collect global brain anatomical imaging data from 30 patients with cognitive susceptibility to depression and 30 normal controls. The difference of gray matter density in the whole brain between the two groups was analyzed and compared with voxel-based morphometrymetric VBM. results: the bilateral cerebral islands and the left cerebellum in patients with cognitive susceptibility to depression were analyzed and compared. The density of gray matter in the right auxiliary motor area and left precentral gyrus was significantly lower than that in the normal group (P 0.001), but in the right inferior frontal gyrus. The density of gray matter in the right middle frontal gyrus and the left cuneate lobe was significantly higher than that in the normal group (P 0.001). Conclusion: there is abnormal gray matter density in patients with cognitive susceptibility to depression, which may be one of the neurobiological mechanisms of cognitive susceptibility to depression.
【作者单位】：中南大学湘雅二医院放射科;湖南农业大学教育学院;中南大学湘雅二医院医学心理中心;
【基金】：国家自然科学基金(81501178)~~
【分类号】：R445.2;R749.4

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