维持性血液透析患者血清超氧化物歧化酶与冠状动脉钙化的关系

发布时间：2018-02-27 14:45

本文关键词： 维持性血液透析冠状动脉钙化超氧化物歧化酶　出处：《山东医药》2017年17期 　论文类型：期刊论文

【摘要】：目的分析维持性血液透析(MHD)患者血清超氧化物歧化酶(SOD)与冠状动脉钙化(CAC)的关系。方法选取MHD患者100例,根据冠状动脉有无钙化分为无钙化组21例和有钙化组79例,记录患者的临床资料和血清SOD、血钙、甘油三酯等实验室检验指标;应用16层螺旋CT检测评估CAC情况;采用Pearson相关分析和Logistic回归分析了解血清SOD与CAC发生的关系。结果糖尿病患病率无钙化组9%(2例),有钙化组36%(29例);心血管事件发生率无钙化组9%(2例),有钙化组30%(24例),有钙化组和无钙化组的糖尿病患病率及心血管事件发生率比较差异有统计学意义(P均0.05)。有CAC者血清SOD水平为(93.66±22.44)U/mL,无CAC者血清SOD水平为(118.76±39.70)U/mL,有CAC者血清SOD水平低于无CAC者(P0.05)。Pearson相关分析发现血清SOD水平与CAC积分呈负相关(r=-0.285,P0.05);Logistic回归分析发现在校正了年龄、白蛋白因素之后,血清SOD水平仍是CAC的独立危险因素(B=-0.044,P0.05)。结论 MHD患者的血清SOD水平与CAC发生有关,血清SOD降低可能是MHD患者CAC发生的相关因素及干预靶点之一。
[Abstract]:Objective to analyze the relationship between serum superoxide dismutase (SOD) and coronary calcification in patients with maintenance hemodialysis (HD). Methods 100 patients with MHD were divided into no calcification group (n = 21) and calcified group (n = 79). The clinical data, serum SOD, serum calcium and triglyceride were recorded and CAC was evaluated by 16-slice spiral CT. Pearson correlation analysis and Logistic regression analysis were used to study the relationship between serum SOD and CAC. Results the prevalence of diabetes mellitus was 9 cases in the no calcification group, 36 cases in the calcified group, 2 cases in the no calcified group, 2 cases in the non calcified group, and 24 cases in the calcified group. There were significant differences in the prevalence of diabetes and the incidence of cardiovascular events between the calcified group and the non-calcified group (P < 0.05). The serum SOD level in the patients with CAC was 93.66 卤22.44 U / mL, the SOD level in the patients without CAC was 118.76 卤39.70 U / mL, the SOD level in the patients with CAC was lower than that in the patients without CAC. Serum SOD level was negatively correlated with CAC score. Logistic regression analysis showed that serum SOD level was adjusted for age. Serum SOD level is still an independent risk factor for CAC after albumin factor. Conclusion the serum SOD level in MHD patients is related to the occurrence of CAC, and the decrease of serum SOD may be one of the related factors and intervention targets of CAC in MHD patients.
【作者单位】：河北北方学院;解放军第309医院;
【分类号】：R459.5;R543.3

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