探讨三阴性与非三阴性乳腺癌超声造影时间-强度曲线的差异

发布时间：2018-03-01 20:07

本文关键词： 三阴性乳腺癌超声检查造影剂　出处：《中国超声医学杂志》2017年05期 　论文类型：期刊论文

【摘要】：目的对比分析三阴性乳腺癌(TNBC)与非三阴性乳腺癌超声造影时间-强度曲线(TIC),初步探讨其产生差异的原因及临床应用价值。方法回顾性分析病理证实乳腺癌患者126例,TNBC组25例,非TNBC组101例,分别记录每个病灶内部及周边TIC曲线参数值,对各参数进行组内(同一病灶内部及周边)及组间(三阴组与非三阴组)比较,并对组间比较有差异的参数行ROC曲线分析,计算分界值。结果组内比较TNBC组仅病灶内部与周边始增时间差异有统计学意义(P0.05),非TNBC组病灶内部与周边始增时间、达峰时间、峰值强度、增强强度差异均有统计学意义(P0.05);组间比较TNBC组内部达峰时间及内部始峰时间差小于非TBNC组,TNBC组内部增强强度、内部上升支斜率、周边增强强度、周边曲线下面积均大于非TNBC组,两两比较差异有统计意学义(P0.05);初步界定内部增强强度16.8,内部上升支斜率0.756,周边增强强度18.45,周边曲线下面积864.66时,病灶均倾向于提示TNBC可能。结论 TIC曲线定量分析可在某种程度上帮助术前筛查TNBC,有一定的临床应用价值。
[Abstract]:Objective to compare and analyze the time-intensity curve of contrast-enhanced contrast-enhanced ultrasound (TICI) between tri-negative breast cancer (TNBC) and non-tri-negative breast cancer, and to explore the causes of the difference and the clinical application value. Methods A retrospective analysis was made on 126 cases of breast cancer confirmed by pathology in TNBC group (25 cases). The parameters of TIC curve inside and around each lesion were recorded in 101 cases of non-#en0# group. The parameters were compared within group (inside and around the same lesion) and between groups (Sanyin group and non-triyin group). ROC curve analysis was used to calculate the boundary value of the parameters compared among groups. Results there was significant difference in the onset time between the focus and the periphery in the TNBC group (P 0.05), and in the non-#en2# group, the onset time and the peak time of the lesion inside and around the lesion were significantly higher than those in the control group, and the difference between the two groups was significant (P < 0.05). There were significant differences in peak intensity and enhancement intensity between groups compared with each other in TNBC group, the difference of internal peak reaching time and internal initial peak time was lower than that of non-TNBC group, and the slope of internal ascending branch and peripheral enhancement intensity were lower than those of non-TNBC group, and the difference of peak time and internal initial peak time of TNBC group was lower than that of non-TNBC group. The area under the peripheral curve was larger than that of the non-#en0# group, and the difference between the two groups was statistically significant (P 0.05), when the internal enhancement intensity was 16.8, the slope of the internal ascending branch was 0.756, the peripheral enhancement intensity was 18.45, and the area under the peripheral curve was 864.66. Conclusion quantitative analysis of TIC curve can help the preoperative screening of TNBC to some extent, which has some clinical application value.
【作者单位】：广西壮族自治区人民医院超声科;
【基金】：广西科学研究与技术开发计划项目(No.桂科攻14124004-1-13) 广西医药卫生自筹经费计划课题(No.Z2016585)
【分类号】：R445.1;R737.9

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