PCT与hs-CRP和WBC及NEU联合检测在老年冠心病患者细菌感染中的应用价值

发布时间：2018-03-02 22:13

本文选题：降钙素原　切入点：超敏C反应蛋白　出处：《中华医院感染学杂志》2017年20期 　论文类型：期刊论文

【摘要】：目的分析降钙素原(PCT)、超敏C反应蛋白(hs-CRP)、白细胞计数(WBC)、中性粒细胞计数(NEU)联合检测在老年冠心病患者细菌感染中的应用价值。方法选取医院2014年1月-2016年12月收治的275例老年冠心病患者为研究对象,根据是否发生感染分为感染组152例、未感染组123例,对感染患者病原菌、不同感染情况、不同感染部位患者入院时的PCT、hs-CRP、WBC、NEU比较并探讨其应用价值。结果发生感染患者共152例,感染率为55.27%,以呼吸道感染为主;共检出病原菌273株,其中革兰阴性菌197株占72.16%,以大肠埃希菌和肺炎克雷伯菌为主;革兰阳性菌76株占27.84%,以金黄色葡萄球菌为主。两组各项血液指标,差异均有统计学意义(P均0.05)。血液感染患者的血清PCT和hs-CRP水平最高,其次为胸腹腔感染患者和呼吸道感染患者,泌尿系统感染患者最低。在四种血液指标中,血清PCT水平在诊断老年冠心病患者细菌性感染中的AUC和Youden指数最高,分别为0.861和0.603,在联合检测四种血液指标时,诊断老年冠心病患者细菌性感染中的AUC和Youden指数均出现了提高,分别为0.943和0.715。结论老年冠心病患者的细菌性感染率较高,其感染部位和病原菌分布具有一定的特征性,联合检测PCT、hs-CRP、WBC、NEU等血液炎症指标可用辅助于老年冠心病患者细菌性感染的早期诊断。
[Abstract]:Objective to analyze the procalcitonin (PCT), high sensitive C reactive protein (hs-CRP), white blood cell count (WBC), neutrophil count (NEU) application value of combined detection of bacterial infection in elderly patients with coronary heart disease in the hospital. Methods the January 2014 -2016 year in December 275 cases of elderly patients with coronary heart disease as the research object according to the occurrence of infection, 152 cases were divided into infection group, non infection group 123 cases, infection of pathogens in patients with infection, different situation, different infection sites of patients with PCT, hs-CRP, WBC, NEU and explore its application value. The results of infection in patients with a total of 152 cases, the infection rate was 55.27%, with the respiratory tract infection; pathogenic bacteria were detected in 273 strains, including 197 strains of gram negative bacteria accounted for 72.16%, Escherichia coli and Klebsiella pneumoniae; 76 strains of gram positive bacteria accounted for 27.84%, Staphylococcus aureus in two groups. The blood indexes, the differences were all Statistically significant (P < 0.05). The blood sera of patients infected with PCT and hs-CRP level is the highest, followed by chest abdominal infection patients and patients with respiratory tract infection, urinary tract infection in four patients. The lowest blood index, serum level of PCT in the diagnosis of bacterial infection in elderly patients with coronary heart disease. AUC and Youden were the highest, respectively. 0.861 and 0.603 in the combined detection of four blood indexes in elderly patients with coronary heart disease, diagnosis of bacterial infection in the AUC and Youden index showed increased, respectively 0.943 and 0.715. conclusion in senile patients with coronary heart disease of bacterial infection rate, the infection sites and pathogens distribution has certain characteristics, combined detection of PCT hs-CRP, WBC, NEU, inflammation index of blood used in the early diagnosis of secondary bacterial infection in elderly patients with coronary heart disease.

【作者单位】：天津市第五中心医院检验科;
【基金】：天津市滨海新区卫生计生委科技基金资助项目(2015BWKY026)
【分类号】：R446;R541.4

【相似文献】