磁共振灌注成像在鼠肝纤维化、肝硬化病理分级中的价值

发布时间：2018-03-05 20:27

  本文选题：灌注加权成像　切入点：肝纤维化　出处：《放射学实践》2017年11期 　论文类型：期刊论文

【摘要】：目的:分析大鼠肝纤维化、肝硬化磁共振灌注成像(MR-PWI)参数特征,评价PWI对肝纤维化、肝硬化病理分级的价值。方法:清洁级SD大鼠100只,体重约150~200g,雄性。将大鼠随机分为2组,对照组(n=16),实验组(n=84);实验组腹腔定点注射硫代乙酰胺(TAA),对照组同期腹腔注射相同剂量生理盐水。建模成功后实验组和对照组分批次进行肝脏常规磁共振扫描及PWI扫描。依据病理结果将肝脏损伤分为5组:肝纤维化0期(对照组)、肝纤维化Ⅰ期(S1),肝纤维化Ⅱ期(S2),肝纤维化Ⅲ期(S3),肝硬化结节期(S4),然后分析灌注参数与病理分级的相关性。结果:共69只大鼠(实验组57只,对照组12只)成功获取PWI图像并进行灌注参数测量,成功率69%(69/100)。各期门静脉诸灌注参数之间差异有统计学意义(P0.05),各期肝实质诸灌注参数之间差异有统计学意义(P0.001)。门静脉TTP及WOR与肝纤维化分级之间存在相关性(r=0.420、-0.464,P0.001)。肝实质TTP及WIR与肝纤维化分级之间存在相关性(r=0.424、-0.488,P0.001)。结论:MR-PWI参数与大鼠肝纤维化、肝硬化的分级有一定相关性。MR-PWI对评价肝纤维化分期具有一定的临床价值。
[Abstract]:Objective: to analyze the characteristics of Mr perfusion imaging (MR-PWI) parameters of hepatic fibrosis and cirrhosis in rats and to evaluate the value of PWI in hepatic fibrosis and pathological grading of cirrhosis. Methods: 100 SD rats of clean grade, weighing about 150 ~ 200g, were randomly divided into two groups. The control group (n = 16) and the experimental group (n = 84) were given intraperitoneal injection of acetamide thioacetamide (TAA) and the same dose of normal saline at the same time. After the model was successfully established, the rats in the experimental group and the control group were scanned by routine magnetic resonance imaging (MRI) and PWI scan in different batches. According to the pathological results, liver injury was divided into 5 groups: hepatic fibrosis stage 0 (control group), hepatic fibrosis stage 鈪，

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