神经内科下呼吸道感染患者病原菌分布特征

发布时间：2018-03-06 10:02

本文选题：神经内科　切入点：住院患者　出处：《中国公共卫生》2017年10期 　论文类型：期刊论文

【摘要】：目的神经内科下呼吸道感染住院患者的病原菌分布特征,为促进患者的合理用药提供参考依据。方法采用方便抽样自大连市选取2家三级甲等医院,随机选取2014年1月1日—2015年12月31日神经内科住院患者合并下呼吸道感染的病历1 600份,提取病原菌分布相关信息。结果共分离出病原菌2 109株,其中革兰阴性菌1 372株,以肺炎克雷伯菌(17.16%,362/2 109)居多;革兰阳性菌624株,以金黄色葡萄球菌(14.32%,302/2 109)居多;真菌113株,以白色假丝酵母菌(2.66%,56/2 109)居多。71.85%(217/302)的金黄色葡萄球菌感染患者进行了耐药性分析,耐药率最低的为万古霉素(0.00%,0/217);78.73%(285/362)的肺炎克雷伯菌感染患者进行了耐药性分析,耐药率最低的为美罗培南(3.16%,9/285)。结论加强住院患者病原菌的监测和耐药性分析,将有助于促进合理用药、预防医院感染,提高治疗的安全性和有效性。
[Abstract]:Objective to study the distribution of pathogenic bacteria in patients with lower respiratory tract infection in Department of Neurology, and to provide a reference for the rational use of drugs. Methods two Grade 3A hospitals were selected from Dalian by convenient sampling. From January 1st 2014 to December 31st 2015, 1 600 cases of neurologic inpatients with lower respiratory tract infection were randomly selected, and the distribution information of pathogens was extracted. Results A total of 2 109 pathogenic bacteria were isolated, among which 1 372 were Gram-negative bacteria. Most of them were Klebsiella pneumoniae (17.16 / 2 109); 624 Gram-positive bacteria, mostly Staphylococcus aureus 14.32% 302 / 2 109); 113 strains of fungi, and 2.66% 56 / 2 109) of Candida albicans. The lowest drug resistance rate was vancomycin (0.000 / 21778.73) in Klebsiella pneumoniae infection patients, and the lowest drug resistance rate was meropenem 3.16 / 2850.Conclusion strengthening the surveillance and drug resistance analysis of pathogens in hospitalized patients will help to promote rational drug use. To prevent nosocomial infection and improve the safety and effectiveness of treatment.
【作者单位】：大连大学附属中山医院神经内科;沈阳药科大学生命科学与生物制药学院临床药学教研室;大连医科大学附属第一医院急诊科;沈阳市第七人民医院呼吸科;辽宁中医药大学解剖组胚教研室;
【基金】：国家自然科学基金(81203004)
【分类号】：R446.5

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