2012-2016年无锡市儿童医院住院患儿肠球菌的分布及耐药性分析

发布时间：2018-03-13 04:03

本文选题：住院患儿　切入点：肠球菌　出处：《现代预防医学》2017年18期 　论文类型：期刊论文

【摘要】：目的了解无锡市儿童医院住院患儿肠球菌的临床分布及耐药特点,为经验治疗提供参考。方法对该院2012-2016年住院患儿送检标本分离出的病原菌进行细菌鉴定和药敏分析,运用WHONET 5.4软件进行统计分析。结果7 414株病原菌中革兰阳性菌有3 469株,其中肠球菌383株,占11.04%(383/3 469)。肠球菌中屎肠球菌273株,粪肠球菌105株,鸟肠球菌5株,分别占71.28%、27.42%及1.30%;主要分布在28 d~1岁及≤28 d患者。主要标本来源为尿液(75.46%),其次为血液(9.66%)。科室来源以新生儿科和儿肾内科为主,分别占27.15%、23.24%。屎肠球菌和粪肠球菌对万古霉素、利奈唑胺和呋喃妥因的耐药率分别为0.73%、2.20%、8.79%及0、0.95%、1.90%;对青霉素及氨苄西林耐药率分别为96.70%、94.87%及2.86%、1.90%。结论住院患儿分离的肠球菌属以屎肠球菌为主,婴儿为主要分离人群,泌尿道为易感部位。屎肠球菌和粪肠球菌对万古霉素、利奈唑胺和呋喃妥因敏感,其中耐利奈唑胺菌株检出率高于耐万古霉素菌株,应引起重视。
[Abstract]:Objective to investigate the clinical distribution and drug resistance characteristics of enterococcus in children hospitalized in Wuxi Children's Hospital, and to provide a reference for empirical treatment. Methods bacterial identification and drug sensitivity analysis were carried out on the pathogenic bacteria isolated from the samples of hospitalized children in Wuxi from 2012 to 2016. Results there were 3 469 gram-positive strains of 7 414 strains of pathogenic bacteria, of which 383 were Enterococcus, accounting for 11.04% 383 / 3 469. There were 273 strains of Enterococcus faecium, 105 strains of Enterococcus faecalis, 5 strains of Enterococcus faecalis, 5 strains of Enterococcus faecium, and 5 strains of Enterococcus faecalis. The main samples were collected from urine 75.46g, followed by blood 9.660.The main sources of the department were neonatal pediatrics and pediatric and pediatric medicine, accounting for 27.15% 23.240.Enterococcus faecium and Enterococcus faecalis against vancomycin, respectively. The drug resistance rates of linazolamine and furantoin were 0.737.20% and 0.0.951.90, respectively. The resistance rates to penicillin and ampicillin were 96.70,94.87% and 2.860.90 respectively. Conclusion Enterococcus faecium is the main isolated group in hospitalized children, and infants are the main isolated population, and the drug resistance rates to penicillin and ampicillin are 96.70,94.87% and 2.86% respectively. Enterococcus faecium and Enterococcus faecalis were sensitive to vancomycin, linazolamine and furantoin.
【作者单位】：无锡市儿童医院药剂科;南京医科大学附属无锡人民医院重症医学科;南京医科大学附属无锡人民医院检验科;
【基金】：国家自然科学基金(81400054) 无锡市卫生局妇幼保健项目(FYKY201405) 无锡市科技局指导性课题(CSZ0N1604)
【分类号】：R446.5;R725.1

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